What fuels the fly: Energy metabolism in Drosophila and its application to the study of obesity and diabetes.
What fuels the fly: Energy metabolism in Drosophila and its application to the study of obesity and diabetes.
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DOI：
10.1126/sciadv.abg4336
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发表时间：
2021-06
期刊：
影响因子：
13.6
通讯作者：
Perrimon N
中科院分区：
文献类型：
--
作者：
Chatterjee N;Perrimon N
果蝇是研究能量代谢调节及其疾病（如肥胖和糖尿病）的有用模型系统。人类和果蝇之间参与能量代谢的器官和代谢途径以及从营养物质产生 ATP 的过程是相似的。这种程度的保护，加上果蝇遗传学的力量，使果蝇成为研究能量稳态的非常有用的模型系统。在这里，我们讨论果蝇中参与能量代谢的主要器官以及它们如何代谢不同的膳食营养素以产生三磷酸腺苷。这些器官中的能量代谢受细胞内在、旁分泌和内分泌信号的控制，果蝇和哺乳动物之间的情况相似。我们描述了这些信号通路如何受到多种生理和环境因素的调节，以适应组织、年龄和环境特定的能量需求差异。最后，我们讨论了几种肥胖和糖尿病的遗传和饮食诱导的果蝇模型，这些模型可用于更好地了解这些代谢疾病的分子基础，从而促进新疗法的开发。
Drosophila is a useful model system to study the regulation of energy metabolism and its diseases like obesity and diabetes. The organs and metabolic pathways involved in energy metabolism, and the process of ATP production from nutrients, are comparable between humans and Drosophila melanogaster. This level of conservation, together with the power of Drosophila genetics, makes the fly a very useful model system to study energy homeostasis. Here, we discuss the major organs involved in energy metabolism in Drosophila and how they metabolize different dietary nutrients to generate adenosine triphosphate. Energy metabolism in these organs is controlled by cell-intrinsic, paracrine, and endocrine signals that are similar between Drosophila and mammals. We describe how these signaling pathways are regulated by several physiological and environmental cues to accommodate tissue-, age-, and environment-specific differences in energy demand. Last, we discuss several genetic and diet-induced fly models of obesity and diabetes that can be leveraged to better understand the molecular basis of these metabolic diseases and thereby promote the development of novel therapies.
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影响因子：
4.5
作者：
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通讯作者：
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作者：
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作者：
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作者：
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DOI：
10.1242/jeb.016451
发表时间：
2008-10
期刊：
The Journal of experimental biology
影响因子：
--
作者：
Bharucha KN;Tarr P;Zipursky SL
通讯作者：
Zipursky SL