Clinical usefulness of the serological gastric biopsy for the diagnosis of chronic autoimmune gastritis.
Clinical usefulness of the serological gastric biopsy for the diagnosis of chronic autoimmune gastritis.
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DOI：
10.1155/2012/520970
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发表时间：
2012
影响因子：
--
通讯作者：
Bizzaro N
中科院分区：
文献类型：
--
作者：
Antico A;Tampoia M;Villalta D;Tonutti E;Tozzoli R;Bizzaro N
瞄准目的探讨抗壁细胞抗体（PCA）、抗内因子抗体（IFA）、抗幽门螺杆菌（Hp）抗体联合血胃泌素检测对慢性自身免疫性胃炎（AIG）的预测价值。方法.我们研究了181例连续性贫血患者，这些患者是由于铁缺乏对口服替代疗法有抵抗力或维生素B12缺乏所致。结果83例患者（45.8%）PCA检测阳性，并接受了胃镜检查和多次胃活检。根据组织学诊断，将PCA阳性患者分为4组：（1）30例慢性萎缩性胃炎患者，其PCA和胃泌素浓度均较高，但未检测到IFA;（2）14例化生性胃萎缩患者，其PCA、IFA和胃泌素浓度均较高;（3）非特异性淋巴细胞性炎症18例，PCA增高，胃泌素水平正常，IFA阴性;（4）多灶性萎缩性胃炎21例，PCA呈“临界”状态，胃泌素正常，IFA阴性，抗Hp阳性率100%。结论.四种血清学标志物的检测在胃炎的诊断分类中特别有效，并且与组织学特征高度相关。因此，该实验室诊断谱可被认为是真实的“血清学活检”。
Aim. To assess the predictive value for chronic autoimmune gastritis (AIG) of the combined assay of anti-parietal-cell antibodies (PCA), anti-intrinsic-factor antibodies (IFA), anti-Helicobacter pylori (Hp) antibodies, and measurement of blood gastrin. Methods. We studied 181 consecutive patients with anemia, due to iron deficiency resistant to oral replacement therapy or to vitamin B12 deficiency. Results. 83 patients (45.8%) tested positive for PCA and underwent gastroscopy with multiple gastric biopsies. On the basis of the histological diagnosis, PCA-positive patients were divided into 4 groups: (1) 30 patients with chronic atrophic gastritis; they had high concentrations of PCA and gastrin and no detectable IFA; (2) 14 subjects with metaplastic gastric atrophy; they had high PCA, IFA, and gastrin; (3) 18 patients with nonspecific lymphocytic inflammation with increased PCA, normal gastrin levels, and absence of IFA; (4) 21 patients with multifocal atrophic gastritis with “borderline” PCA, normal gastrin, absence of IFA and presence of anti-Hp in 100% of the cases. Conclusions. The assay of four serological markers proved particularly effective in the diagnostic classification of gastritis and highly correlated with the histological profile. As such, this laboratory diagnostic profile may be considered an authentic “serological biopsy.”
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影响因子：
15.3
作者：
Amedei, A;Bergman, MP;Appelmelk, BJ;Azzurri, A;Benagiano, M;Tamburini, C;van der Zee, R;Telford, JL;Vandenbroucke-Grauls, CMJE;D'Elios, MM;Del Prete, G
通讯作者：
Del Prete, G
影响因子：
5.6
作者：
Jevremovic, Dragan;Torbenson, Michael;Abraham, Susan C.
通讯作者：
Abraham, Susan C.
影响因子：
29.4
作者：
Martinelli, TM;vanDriel, IR;Toh, BH
通讯作者：
Toh, BH
影响因子：
7.7
作者：
Tucci, Antonio;Bisceglia, Michele;Caletti, Giancarlo
通讯作者：
Caletti, Giancarlo
影响因子：
1.9
作者：
Korstanje, A;den Hartog, G;Lamers, CBHW
通讯作者：
Lamers, CBHW