Sleep/Wake Behavior and EEG Signatures of the TgF344-AD Rat Model at the Prodromal Stage.
Sleep/Wake Behavior and EEG Signatures of the TgF344-AD Rat Model at the Prodromal Stage.
复制标题
DOI：
10.3390/ijms21239290
复制
发表时间：
2020-12-05
影响因子：
5.6
通讯作者：
García PS
中科院分区：
文献类型：
--
作者：
Kreuzer M;Keating GL;Fenzl T;Härtner L;Sinon CG;Hajjar I;Ciavatta V;Rye DB;García PS
对与大鼠家族性阿尔茨海默病（AD）相关的两个最常见基因（APPsw, PS1ΔE9）进行转基因修饰，产生了一种啮鼠模型，该模型在没有基因tau蛋白修饰的情况下出现了AD的病理体征。我们使用17个月大的AD大鼠（n = 8）和年龄匹配的对照组（AC, n = 7），通过24小时的脑电图记录（12:12h暗光周期）来评估清醒（WAKE）、非快速眼动睡眠（NREM）和快速眼动睡眠（REM）期间的睡眠行为和脑电图特征的差异。我们发现，AD大鼠有更多的睡眠-觉醒转换，快速眼动和非快速眼动发作时间更短的可能性增加。AD大鼠的相对光谱功率分布也更为均匀。利用差分熵对脑电信息含量进行分析，发现AD动物在WAKE期间的脑电信息较少，而在NREM期间的脑电信息较多。这似乎表明，AD诱导的抑制网络功能改变可能引起脑电图活动的有限范围变化，反映在GABAAR-β2表达增加，但AD动物的GAD-67没有增加。综上所述，该转基因阿尔茨海默病大鼠模型在清醒时表现出较不明显的WAKE脑电图特征，在睡眠时表现出较不典型的睡眠特征。
Transgenic modification of the two most common genes (APPsw, PS1ΔE9) related to familial Alzheimer’s disease (AD) in rats has produced a rodent model that develops pathognomonic signs of AD without genetic tau-protein modification. We used 17-month-old AD rats (n = 8) and age-matched controls (AC, n = 7) to evaluate differences in sleep behavior and EEG features during wakefulness (WAKE), non-rapid eye movement sleep (NREM), and rapid eye movement sleep (REM) over 24-h EEG recording (12:12h dark–light cycle). We discovered that AD rats had more sleep–wake transitions and an increased probability of shorter REM and NREM bouts. AD rats also expressed a more uniform distribution of the relative spectral power. Through analysis of information content in the EEG using entropy of difference, AD animals demonstrated less EEG information during WAKE, but more information during NREM. This seems to indicate a limited range of changes in EEG activity that could be caused by an AD-induced change in inhibitory network function as reflected by increased GABAAR-β2 expression but no increase in GAD-67 in AD animals. In conclusion, this transgenic rat model of Alzheimer’s disease demonstrates less obvious EEG features of WAKE during wakefulness and less canonical features of sleep during sleep.
登录
查看更多内容
影响因子：
4.8
作者：
Ferreri, Florinda;Vecchio, Fabrizio;Di Lazzaro, Vincenzo
通讯作者：
Di Lazzaro, Vincenzo
影响因子：
3.4
作者：
Berntson, GG;Shafi, R;Sarter, M
通讯作者：
Sarter, M
影响因子：
4.7
作者：
Dustman, RE;Shearer, DE;Emmerson, RY
通讯作者：
Emmerson, RY
影响因子：
3.4
作者：
Harkany, T;Abrahám, I;Luiten, PGM
通讯作者：
Luiten, PGM
影响因子：
1.5
作者：
Ferguson, Christopher J.
通讯作者：
Ferguson, Christopher J.