Correlation between Intravoxel Incoherent Motion Magnetic Resonance Imaging Derived Metrics and Serum Soluble CD40 Ligand Level in an Embolic Canine Stroke Model.
Correlation between Intravoxel Incoherent Motion Magnetic Resonance Imaging Derived Metrics and Serum Soluble CD40 Ligand Level in an Embolic Canine Stroke Model.
复制标题
犬栓塞中风模型中体素内不相干运动磁共振成像衍生指标与血清可溶性 CD40 配体水平之间的相关性
DOI：
10.3348/kjr.2017.18.5.835
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发表时间：
2017-09
影响因子：
4.8
通讯作者：
Liu S
中科院分区：
文献类型：
--
作者：
Xu XQ;Wu CJ;Lu SS;Gao QQ;Zu QQ;Liu XL;Shi HB;Liu S
目的探讨犬脑栓塞模型中体素内非相干运动（IVIM）成像定量指标与血清可溶性CD 40配体（sCD 40 L）水平的关系。材料与方法24只Beagle犬建立大脑中动脉闭塞模型。根据造模后4.5h血清sCD 40 L水平将实验犬分为低、高sCD 40 L组。在模型建立后4.5小时使用范围为0至900 s/mm 2的10个B值扫描IVIM成像。计算缺血性病变的定量指标扩散系数（D）、假扩散系数（D*）和灌注分数（f）。使用以下公式通过对侧半球将缺血性病变的定量度量标准化：标准化D = Dstroke / Dcontralateral。使用t检验比较低sCD 40 L组和高sCD 40 L组之间IVIM指标的差异。Pearson相关分析确定IVIM指标与血清sCD 40 L水平之间的关系。结果高sCD 40 L组的f值和标准化f值均显著低于低sCD 40 L组（f，p < 0.001;标准化f，p < 0.001）。两组之间的D*、标准化D*、D或标准化D值均无显著差异（所有p > 0.05）。f值和标准化f值均与血清sCD 40 L水平呈负相关（f，r =-0.789，p < 0.001;标准化f，r =-0.823，p < 0.001）。而血清sCD 40 L水平与D*、标准化D*、D、标准化D均无显著相关性（均p > 0.05）。结论IVIM显像的f值与血清sCD 40 L水平呈负相关。f值可作为评价缺血性脑卒中超急性期微血管血栓形成的潜在影像学指标。
Objective To determine the relationship between intravoxel incoherent motion (IVIM) imaging derived quantitative metrics and serum soluble CD40 ligand (sCD40L) level in an embolic canine stroke model. Materials and Methods A middle cerebral artery occlusion model was established in 24 beagle dogs. Experimental dogs were divided into low- and high-sCD40L group according to serum sCD40L level at 4.5 hours after establishing the model. IVIM imaging was scanned at 4.5 hours after model establishment using 10 b values ranging from 0 to 900 s/mm2. Quantitative metrics diffusion coefficient (D), pseudodiffusion coefficient (D*), and perfusion fraction (f) of ischemic lesions were calculated. Quantitative metrics of ischemic lesions were normalized by contralateral hemisphere using the following formula: normalized D = Dstroke / Dcontralateral. Differences in IVIM metrics between the low- and high-sCD40L groups were compared using t test. Pearson's correlation analyses were performed to determine the relationship between IVIM metrics and serum sCD40L level. Results The high-sCD40L group showed significantly lower f and normalized f values than the low-sCD40L group (f, p < 0.001; normalized f, p < 0.001). There was no significant difference in D*, normalized D*, D, or normalized D value between the two groups (All p > 0.05). Both f and normalized f values were negatively correlated with serum sCD40L level (f, r = −0.789, p < 0.001; normalized f, r = −0.823, p < 0.001). However, serum sCD40L level had no significant correlation with D*, normalized D*, D, or normalized D (All p > 0.05). Conclusion The f value derived from IVIM imaging was negatively correlated with serum sCD40L level. f value might serve as a potential imaging biomarker to assess the formation of microvascular thrombosis in hyperacute period of ischemic stroke.
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