Regulation of Mitochondrial Quality Control by Natural Drugs in the Treatment of Cardiovascular Diseases: Potential and Advantages.
Regulation of Mitochondrial Quality Control by Natural Drugs in the Treatment of Cardiovascular Diseases: Potential and Advantages.
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天然药物在心血管疾病治疗中对线粒体质量控制的调节：潜力和优势。
DOI：
10.3389/fcell.2020.616139
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发表时间：
2020
影响因子：
5.5
通讯作者：
Zhao Y
中科院分区：
文献类型：
--
作者：
Chang X;Zhang W;Zhao Z;Ma C;Zhang T;Meng Q;Yan P;Zhang L;Zhao Y
线粒体是双膜细胞细胞器，可为心肌细胞提供所需的能量和代谢中间体。线粒体呼吸链缺陷，结构异常和DNA突变会影响心肌细胞的正常功能，从而导致细胞内钙离子稳态，活性氧的产生和凋亡。线粒体质量控制（MQC）是一个重要的过程，它在心肌细胞中保持线粒体稳态，涉及多层调节机制，例如线粒体裂变和融合，线粒体能量，线粒体能量替代疗法，线粒体镇压式抗抗形性链和MIRICOCHONDRIAIAN和MISIROCHONDRRIAIAN和MISIRIRAIN。此外，MQC在各种心血管疾病（CVD）的病理机制中起作用。近年来，在CVD的背景下，天然植物，药物和活性成分对MQC的调节作用受到了极大的关注。天然药物的有效活性成分可以影响线粒体中能量供应物质的产生，干扰与线粒体能量需求相关的基因的表达，并调节MQC调节的各种机制。因此，这些成分对CVD具有治疗作用。这篇综述提供了有关CVD的新型治疗选择和针对MQC的新药物的有用信息。
Mitochondria are double-membraned cellular organelles that provide the required energy and metabolic intermediates to cardiomyocytes. Mitochondrial respiratory chain defects, structure abnormalities, and DNA mutations can affect the normal function of cardiomyocytes, causing an imbalance in intracellular calcium ion homeostasis, production of reactive oxygen species, and apoptosis. Mitochondrial quality control (MQC) is an important process that maintains mitochondrial homeostasis in cardiomyocytes and involves multi-level regulatory mechanisms, such as mitophagy, mitochondrial fission and fusion, mitochondrial energy metabolism, mitochondrial antioxidant system, and mitochondrial respiratory chain. Furthermore, MQC plays a role in the pathological mechanisms of various cardiovascular diseases (CVDs). In recent years, the regulatory effects of natural plants, drugs, and active ingredients on MQC in the context of CVDs have received significant attention. Effective active ingredients in natural drugs can influence the production of energy-supplying substances in the mitochondria, interfere with the expression of genes associated with mitochondrial energy requirements, and regulate various mechanisms of MQC modulation. Thus, these ingredients have therapeutic effects against CVDs. This review provides useful information about novel treatment options for CVDs and development of novel drugs targeting MQC.
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影响因子：
3.9
作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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