The current state of knowledge of the immune ecosystem in alopecia areata.
The current state of knowledge of the immune ecosystem in alopecia areata.
复制标题
DOI：
10.1016/j.autrev.2022.103061
复制
发表时间：
2022-05
影响因子：
13.6
通讯作者：
Jabbari, Ali
中科院分区：
文献类型：
--
作者：
Connell, Samuel J.;Jabbari, Ali
斑秃（AA）是一种自身免疫性疾病，约占总人口的2%。AA患者最常见的表现是头皮上一个或多个圆形区域的脱发。一小部分患者发展为更严重的疾病形式，在某些情况下累及所有体表。健康的毛囊生长期被认为是一个免疫特权部位，被描述为一个抑制炎症免疫反应的环境。然而，在AA中，这种免疫特权状态崩溃，标志着毛囊成为免疫系统的目标，导致淋巴细胞在毛囊周围和毛囊内浸润。毛囊免疫应答的炎症生态系统的复杂性，以及AA中细胞和可溶性参与者之间的关系仍然不完全清楚。许多研究表明，病变毛囊周围存在各种免疫细胞；然而，人们对它们各自在AA发病机制中的作用知之甚少。进一步了解AA的发病机制对于发现有效且几乎没有意外效应的靶向治疗方法至关重要。
Alopecia areata (AA) is an autoimmune disease that affects approximately 2% of the general population. Patients with AA most commonly present with one or more patches of hair loss on the scalp in defined circular areas. A fraction of patients progress to more severe forms of the disease, in some cases with involvement of all body surfaces. The healthy anagen stage hair follicle is considered an immune privileged site, described as an environment that suppresses inflammatory immune responses. However, in AA, this immune privileged state collapses and marks the hair follicle as a target for the immune system, resulting in peri- and intrafollicular infiltration by lymphocytes. The complexity of the inflammatory ecosystem of the immune response to the hair follicle, and the relationships between the cellular and soluble participants, in AA remains incompletely understood. Many studies have demonstrated the presence of various immune cells around diseased hair follicles; however, often little is known about their respective contributions to AA pathogenesis. Furthering our understanding of the mechanisms of disease in AA is essential for the novel identification of targeted therapeutics that are efficacious and have few unintended effects.
登录
查看更多内容
DOI：
10.4049/jimmunol.1100657
发表时间：
2012-01-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Alli R;Nguyen P;Boyd K;Sundberg JP;Geiger TL
通讯作者：
Geiger TL
影响因子：
158.5
作者：
Castro, M.;Corren, J.;Teper, A.
通讯作者：
Teper, A.
影响因子：
3.6
作者：
Agamia, Naglaa;Apalla, Zoe;Abozeid, Sami
通讯作者：
Abozeid, Sami
影响因子：
3.6
作者：
Atwa, Mona A.;Youssef, Nahed;Bayoumy, Nervana M.
通讯作者：
Bayoumy, Nervana M.
影响因子：
16.6
作者：
Betz RC;Petukhova L;Ripke S;Huang H;Menelaou A;Redler S;Becker T;Heilmann S;Yamany T;Duvic M;Hordinsky M;Norris D;Price VH;Mackay-Wiggan J;de Jong A;DeStefano GM;Moebus S;Böhm M;Blume-Peytavi U;Wolff H;Lutz G;Kruse R;Bian L;Amos CI;Lee A;Gregersen PK;Blaumeiser B;Altshuler D;Clynes R;de Bakker PIW;Nöthen MM;Daly MJ;Christiano AM
通讯作者：
Christiano AM