A Daily-Updated Database and Tools for Comprehensive SARS-CoV-2 Mutation-Annotated Trees.
A Daily-Updated Database and Tools for Comprehensive SARS-CoV-2 Mutation-Annotated Trees.
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DOI:
10.1093/molbev/msab264
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发表时间:
2021-12-09
影响因子:
10.7
通讯作者:
Turakhia Y
中科院分区:
文献类型:
--
作者:
McBroome J;Thornlow B;Hinrichs AS;Kramer A;De Maio N;Goldman N;Haussler D;Corbett-Detig R;Turakhia Y
The vast scale of SARS-CoV-2 sequencing data has made it increasingly challenging to comprehensively analyze all available data using existing tools and file formats. To address this, we present a database of SARS-CoV-2 phylogenetic trees inferred with unrestricted public sequences, which we update daily to incorporate new sequences. Our database uses the recently proposed mutation-annotated tree (MAT) format to efficiently encode the tree with branches labeled with parsimony-inferred mutations, as well as Nextstrain clade and Pango lineage labels at clade roots. As of June 9, 2021, our SARS-CoV-2 MAT consists of 834,521 sequences and provides a comprehensive view of the virus’ evolutionary history using public data. We also present matUtils—a command-line utility for rapidly querying, interpreting, and manipulating the MATs. Our daily-updated SARS-CoV-2 MAT database and matUtils software are available at http://hgdownload.soe.ucsc.edu/goldenPath/wuhCor1/UShER_SARS-CoV-2/ and https://github.com/yatisht/usher, respectively.
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影响因子:
64.8
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Clark, Andrew G.;Eisen, Michael B.;MacCallum, Iain
通讯作者:
MacCallum, Iain
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Chiu, Charles Y.
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Turakhia, Yatish;Thornlow, Bryan;Hinrichs, Angie S.;De Maio, Nicola;Gozashti, Landen;Lanfear, Robert;Haussler, David;Corbett-Detig, Russell
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影响因子:
4.5
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通讯作者:
Corbett-Detig R
影响因子:
5.4
作者:
Wang, TH;Donaldson, YK;Simmonds, P
通讯作者:
Simmonds, P