Parvalbumin-positive basket cells differentiate among hippocampal pyramidal cells.
Parvalbumin-positive basket cells differentiate among hippocampal pyramidal cells.
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DOI：
10.1016/j.neuron.2014.03.034
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发表时间：
2014-06-04
期刊：
影响因子：
16.2
通讯作者：
Soltesz I
中科院分区：
文献类型：
--
作者：
Lee SH;Marchionni I;Bezaire M;Varga C;Danielson N;Lovett-Barron M;Losonczy A;Soltesz I
CA1 pyramidal cells (PCs) are not homogeneous, but rather can be grouped by molecular, morphological, and functional properties. However, less is known about synaptic sources differentiating PCs. Using paired recordings in vitro, 2-photon Ca2+ imaging in vivo and computational modeling, we found that parvalbumin-expressing basket cells (PVBCs) evoked greater inhibition in CA1 PCs located in the deep compared to superficial layer of stratum pyramidale. In turn, analysis of reciprocal connectivity revealed more frequent excitatory inputs to PVBCs by superficial PCs, demonstrating bias in target selection by both the excitatory and inhibitory local connections in CA1. Additionally, PVBCs further segregated among deep PCs, preferentially innervating the amygdala-projecting PCs but receiving preferential excitation from the prefrontal cortex-projecting PCs, thus revealing distinct perisomatic inhibitory interactions between separate output channels. These results demonstrate the presence of heterogeneous PVBC-PC microcircuits, potentially contributing to the sparse and distributed structure of hippocampal network activity.
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影响因子：
2.5
作者：
FARINAS, I;DEFELIPE, J
通讯作者：
DEFELIPE, J
DOI：
10.1523/jneurosci.6238-09.2010
发表时间：
2010-06-09
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Lee SH;Földy C;Soltesz I
通讯作者：
Soltesz I
特定中间神经元的激活可提高 V1 特征选择性和视觉感知。
影响因子：
64.8
作者：
Lee, Seung-Hee;Kwan, Alex C.;Zhang, Siyu;Phoumthipphavong, Victoria;Flannery, John G.;Masmanidis, Sotiris C.;Taniguchi, Hiroki;Huang, Z. Josh;Zhang, Feng;Boyden, Edward S.;Deisseroth, Karl;Dan, Yang
通讯作者：
Dan, Yang
影响因子：
16.2
作者：
Lee AT;Gee SM;Vogt D;Patel T;Rubenstein JL;Sohal VS
通讯作者：
Sohal VS
影响因子：
16.2
作者：
Fino E;Yuste R
通讯作者：
Yuste R