Dense inhibitory connectivity in neocortex.
Dense inhibitory connectivity in neocortex.
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DOI：
10.1016/j.neuron.2011.02.025
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发表时间：
2011-03-24
期刊：
影响因子：
16.2
通讯作者：
Yuste R
中科院分区：
文献类型：
--
作者：
Fino E;Yuste R
新皮层回路的连接图仍然是未知的，关于皮层神经元是否有特定的连接，也有相互矛盾的数据。为了研究皮层微电路的基本结构，我们使用了一种新的双光子光刺激技术，该技术能够以单细胞分辨率系统地映射突触连接。我们绘制了小鼠额叶皮层上层生长抑素阳性GABA能中间神经元和锥体细胞之间的抑制性连接。大多数，有时是所有的抑制性神经元都与每一个取样的锥体细胞局部相连。这种密集的抑制性连接在年轻和成熟的发育年龄都有发现。相邻锥体细胞的抑制性神经支配是相似的，不管它们之间是否连接。我们的结论是，局部抑制连接是混杂的，不形成子网络，可以接近一个完全连接的突触矩阵的理论极限。
The connectivity diagram of neocortical circuits is still unknown, and there are conflicting data as to whether cortical neurons are wired specifically or not. To investigate the basic structure of cortical microcircuits, we use a novel two-photon photostimulation technique that enables the systematic mapping of synaptic connections with single-cell resolution. We map the inhibitory connectivity between upper layers somatostatin-positive GABAergic interneurons and pyramidal cells in mouse frontal cortex. Most, and sometimes all, inhibitory neurons are locally connected to every sampled pyramidal cell. This dense inhibitory connectivity is found at both young and mature developmental ages. Inhibitory innervation of neighboring pyramidal cells is similar, regardless of whether they are connected among themselves or not. We conclude that local inhibitory connectivity is promiscuous, does not form subnetworks and can approach the theoretical limit of a completely connected synaptic matrix.
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