Insomnia Phenotypes Based on Objective Sleep Duration in Adolescents: Depression Risk and Differential Behavioral Profiles.
Insomnia Phenotypes Based on Objective Sleep Duration in Adolescents: Depression Risk and Differential Behavioral Profiles.
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基于青少年客观睡眠持续时间的失眠表型：抑郁风险和差异行为特征。
DOI：
10.3390/brainsci6040059
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发表时间：
2016-12-13
期刊：
影响因子：
3.3
通讯作者：
Bixler EO
中科院分区：
文献类型：
--
作者：
Fernandez-Mendoza J;Calhoun SL;Vgontzas AN;Li Y;Gaines J;Liao D;Bixler EO
Based on previous studies on the role of objective sleep duration in predicting morbidity in individuals with insomnia, we examined the role of objective sleep duration in differentiating behavioral profiles in adolescents with insomnia symptoms. Adolescents from the Penn State Child Cohort (n = 397, ages 12–23, 54.7% male) underwent a nine-hour polysomnography (PSG), clinical history, physical examination and psychometric testing, including the Child or Adult Behavior Checklist and Pediatric Behavior Scale. Insomnia symptoms were defined as a self-report of difficulty falling and/or staying asleep and objective “short” sleep duration as a PSG total sleep time ≤7 h. A significant interaction showed that objective short sleep duration modified the association of insomnia symptoms with internalizing problems. Consistently, adolescents with insomnia symptoms and short sleep duration were characterized by depression, rumination, mood dysregulation and social isolation, while adolescents with insomnia symptoms and normal sleep duration were characterized by rule-breaking and aggressive behaviors and, to a lesser extent, rumination. These findings indicate that objective sleep duration is useful in differentiating behavioral profiles among adolescents with insomnia symptoms. The insomnia with objective short sleep duration phenotype is associated with an increased risk of depression earlier in the lifespan than previously believed.
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影响因子：
4.1
作者：
Carney CE;Harris AL;Moss TG;Edinger JD
通讯作者：
Edinger JD
影响因子：
5.6
作者：
Ohayon, MM;Carskadon, MA;Vitiello, MV
通讯作者：
Vitiello, MV
影响因子：
5.6
作者：
Gregory, Alice M.;Rijsdijk, Fruehling V.;Eley, Thalia C.
通讯作者：
Eley, Thalia C.
儿童失眠症状，客观睡眠持续时间和下丘脑 - 垂体 - 肾上腺活性。
影响因子：
5.5
作者：
Fernandez-Mendoza J;Vgontzas AN;Calhoun SL;Vgontzas A;Tsaoussoglou M;Gaines J;Liao D;Chrousos GP;Bixler EO
通讯作者：
Bixler EO
DOI：
10.1097/01.chi/0000122798.47863.a5
发表时间：
2004-06-01
影响因子：
13.3
作者：
Gregory, AM;Eley, TC;Plomin, R
通讯作者：
Plomin, R