Early detection of SARS-CoV-2 and other infections in solid organ transplant recipients and household members using wearable devices.
Early detection of SARS-CoV-2 and other infections in solid organ transplant recipients and household members using wearable devices.
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使用可穿戴设备在实体器官移植受者和家庭成员中早期检测SARS-CoV-2和其他感染。
DOI：
10.1111/tri.13860
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Snyder MP
中科院分区：
文献类型：
--
作者：
Keating BJ;Mukhtar EH;Elftmann ED;Eweje FR;Gao H;Ibrahim LI;Kathawate RG;Lee AC;Li EH;Moore KA;Nair N;Chaluvadi V;Reason J;Zanoni F;Honkala AT;Al-Ali AK;Abdullah Alrubaish F;Ahmad Al-Mozaini M;Al-Muhanna FA;Al-Romaih K;Goldfarb SB;Kellogg R;Kiryluk K;Kizilbash SJ;Kohut TJ;Kumar J;O'Connor MJ;Rand EB;Redfield RR;Rolnik B;Rossano J;Sanchez PG;Alavi A;Bahmani A;Bogu GK;Brooks AW;Metwally AA;Mishra T;Marks SD;Montgomery RA;Fishman JA;Amaral S;Jacobson PA;Wang M;Snyder MP
SARS-CoV-2在全球范围内日益流行以及由此引发的新冠肺炎疾病大流行给实体器官移植受者的临床管理带来了严重的担忧。可穿戴设备可以测量生物识别中的生理变化，包括心率、心率变异性、体温、呼吸、活动(如每天走的步数)和睡眠模式，以及血氧饱和度，这些设备显示出在临床症状出现之前早期检测感染的实用价值。使用初步可穿戴数据集开发的最新算法表明，80%的成年人在临床症状之前就能检测到SARS-CoV-2。在SOTR及其家庭成员中及早发现SARS-CoV-2、流感和其他病原体，可以促进早期干预，如自我隔离和相关感染的早期临床处理(S)。这里回顾了正在进行的测试可穿戴设备(如智能手表)在普通人群中早期检测SARS-CoV-2和其他感染的效用的研究，以及在儿科和成人SOTR及其家庭成员中大规模实施这些过程的实际挑战。资源和后勤，包括移植特异性分析管道，以解决混杂因素，如多药和合并症，所需的儿科和成人SOTR研究，以强有力的早期发现SARS冠状病毒2，以及其他感染，也进行了审查。
The increasing global prevalence of SARS‐CoV‐2 and the resulting COVID‐19 disease pandemic pose significant concerns for clinical management of solid organ transplant recipients (SOTR). Wearable devices that can measure physiologic changes in biometrics including heart rate, heart rate variability, body temperature, respiratory, activity (such as steps taken per day) and sleep patterns, and blood oxygen saturation show utility for the early detection of infection before clinical presentation of symptoms. Recent algorithms developed using preliminary wearable datasets show that SARS‐CoV‐2 is detectable before clinical symptoms in >80% of adults. Early detection of SARS‐CoV‐2, influenza, and other pathogens in SOTR, and their household members, could facilitate early interventions such as self‐isolation and early clinical management of relevant infection(s). Ongoing studies testing the utility of wearable devices such as smartwatches for early detection of SARS‐CoV‐2 and other infections in the general population are reviewed here, along with the practical challenges to implementing these processes at scale in pediatric and adult SOTR, and their household members. The resources and logistics, including transplant‐specific analyses pipelines to account for confounders such as polypharmacy and comorbidities, required in studies of pediatric and adult SOTR for the robust early detection of SARS‐CoV‐2, and other infections are also reviewed.
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