Intra-Areal Visual Topography in Primate Brains Mapped with Probabilistic Tractography of Diffusion-Weighted Imaging.
Intra-Areal Visual Topography in Primate Brains Mapped with Probabilistic Tractography of Diffusion-Weighted Imaging.
复制标题
DOI：
10.1093/cercor/bhab364
复制
发表时间：
2022-06-07
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
非侵入性弥散加权磁共振成像（dMRI）可用于绘制完整大脑中不同区域之间的神经连接，但所达到的标准分辨率从根本上限制了此类地图的灵敏度。我们研究了高分辨率死后dMRI和概率性纤维束成像在猕猴大脑中的敏感性和特异性，以产生外侧膝状体核（LGN）和纹外皮质视觉区V5/MT的视网膜定位图，基于它们与先前建立的初级视觉皮层（V1）的功能性视网膜定位图的地形连接。我们还复制了大细胞和小细胞LGN隔室与V1跨视野位置的差异连接。基于dMRI数据的预测地形图在很大程度上与LGN和V5/MT的视网膜病变相匹配。此外，纤维束成像的基础上，在体内的dMRI数据从相同的猕猴大脑在标准场强（3 T）收购在许多情况下产生了可比的地形图。我们的结论是，基于dMRI的纤维束成像是足够敏感的，以揭示内在的组织拓扑结构组织的神经结构和它们所产生的功能组织之间的有序连接。
Noninvasive diffusion-weighted magnetic resonance imaging (dMRI) can be used to map the neural connectivity between distinct areas in the intact brain, but the standard resolution achieved fundamentally limits the sensitivity of such maps. We investigated the sensitivity and specificity of high-resolution postmortem dMRI and probabilistic tractography in rhesus macaque brains to produce retinotopic maps of the lateral geniculate nucleus (LGN) and extrastriate cortical visual area V5/MT based on their topographic connections with the previously established functional retinotopic map of primary visual cortex (V1). We also replicated the differential connectivity of magnocellular and parvocellular LGN compartments with V1 across visual field positions. Predicted topographic maps based on dMRI data largely matched the established retinotopy of both LGN and V5/MT. Furthermore, tractography based on in vivo dMRI data from the same macaque brains acquired at standard field strength (3T) yielded comparable topographic maps in many cases. We conclude that tractography based on dMRI is sensitive enough to reveal the intrinsic organization of ordered connections between topographically organized neural structures and their resultant functional organization.
登录
查看更多内容
影响因子：
5.7
作者：
Cottaar M;Bastiani M;Boddu N;Glasser MF;Haber S;van Essen DC;Sotiropoulos SN;Jbabdi S
通讯作者：
Jbabdi S
DOI：
10.1073/pnas.0500003102
发表时间：
2005-05-17
影响因子：
11.1
作者：
Dougherty, RF;Ben-Shachar, M;Wandell, BA
通讯作者：
Wandell, BA
影响因子：
5.7
作者：
Chowdhury, Rumana;Lambert, Christian;Duezel, Emrah
通讯作者：
Duezel, Emrah
影响因子：
3.7
作者：
Ahmed, Bashir;Cordery, Patricia M.;Krug, Kristine
通讯作者：
Krug, Kristine
影响因子：
1.8
作者：
BARLOW, HB
通讯作者：
BARLOW, HB