Duration of lactation and maternal adipokines at 3 years postpartum.
Duration of lactation and maternal adipokines at 3 years postpartum.
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DOI：
10.2337/db10-0637
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发表时间：
2011-04
期刊：
影响因子：
7.7
通讯作者：
Rich-Edwards J
中科院分区：
文献类型：
--
作者：
Stuebe AM;Mantzoros C;Kleinman K;Gillman MW;Rifas-Shiman S;Gunderson EP;Rich-Edwards J
哺乳与降低母亲患2型糖尿病、代谢综合征和心血管疾病的风险有关。我们研究了母乳喂养持续时间和产后3年母亲脂肪因子之间的关系。我们使用线性回归将哺乳期持续时间与产后3年时的母体瘦素、脂联素、生长激素释放肽和肽YY（PYY）联系起来，其中570名参与者具有产后3年的血液样本（178名禁食），前瞻性收集哺乳史，并且在Viva项目中没有干预妊娠，这是一项母亲和儿童的队列研究。共有88%的母亲开始母乳喂养，26%的母亲母乳喂养≥12个月，42%的母亲纯母乳喂养≥3个月。在多变量分析中，我们发现完全母乳喂养的持续时间与PYY和ghrelin直接相关，纯母乳喂养的持续时间与ghrelin直接相关（从未纯母乳喂养的预测均值：790.6 pg/mL，而纯母乳喂养≥6个月的预测均值：1，008.1 pg/mL; P < 0.01），校正了孕前BMI、妊娠期体重增加、糖尿病家族史、产次、吸烟状况和年龄。我们在多变量校正模型中发现纯母乳喂养持续时间与脂联素之间存在非线性相关性。在这项前瞻性队列研究中，我们发现哺乳期的持续时间与产后3年的ghrelin和PYY之间存在直接关系。
Lactation has been associated with reduced maternal risk of type 2 diabetes, the metabolic syndrome, and cardiovascular disease. We examined the relationship between breastfeeding duration and maternal adipokines at 3 years postpartum. We used linear regression to relate the duration of lactation to maternal leptin, adiponectin, ghrelin, and peptide YY (PYY) at 3 years postpartum among 570 participants with 3-year postpartum blood samples (178 fasting), prospectively collected lactation history, and no intervening pregnancy in Project Viva, a cohort study of mothers and children. A total of 88% of mothers had initiated breastfeeding, 26% had breastfed ≥12 months, and 42% had exclusively breastfed for ≥3 months. In multivariate analyses, we found that duration of total breastfeeding was directly related to PYY and ghrelin, and exclusive breastfeeding duration was directly related to ghrelin (predicted mean for never exclusively breastfeeding: 790.6 pg/mL vs. ≥6 months of exclusive breastfeeding: 1,008.1 pg/mL; P < 0.01) at 3 years postpartum, adjusting for pregravid BMI, gestational weight gain, family history of diabetes, parity, smoking status, and age. We found a nonlinear pattern of association between exclusive breastfeeding duration and adiponectin in multivariate-adjusted models. In this prospective cohort study, we found a direct relationship between the duration of lactation and both ghrelin and PYY at 3 years postpartum.
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DOI：
10.1089/15246090152563560
发表时间：
2001-09-01
期刊：
JOURNAL OF WOMENS HEALTH & GENDER-BASED MEDICINE
影响因子：
--
作者：
Lankarani-Fard, A;Kritz-Silverstein, D;Goodman-Gruen, D
通讯作者：
Goodman-Gruen, D
影响因子：
7.1
作者：
Larson-Meyer, D. Enette;Ravussin, Eric;DeJonge, Lilian
通讯作者：
DeJonge, Lilian
影响因子：
5.9
作者：
Schwarz, Eleanor Bimla;Brown, Jeanette S.;Thom, David
通讯作者：
Thom, David
影响因子：
4.2
作者：
Light, KC;Smith, TE;Amico, JA
通讯作者：
Amico, JA
影响因子：
4
作者：
Oliveira, E.;Pinheiro, C. R.;Lisboa, P. C.
通讯作者：
Lisboa, P. C.