Human Stem Cell Models of SARS-CoV-2 Infection in the Cardiovascular System.
Human Stem Cell Models of SARS-CoV-2 Infection in the Cardiovascular System.
复制标题
DOI：
10.1007/s12015-021-10229-4
复制
发表时间：
2021-12
影响因子：
4.8
通讯作者：
Zhao MT
中科院分区：
文献类型：
--
作者：
Ernzen K;Trask AJ;Peeples ME;Garg V;Zhao MT
导致2019冠状病毒病（COVID-19）的病毒，严重急性呼吸道综合征冠状病毒2（SARS-CoV-2），迄今已感染超过1.9亿人，导致全球大流行。SARS-CoV-2依赖于其刺突糖蛋白与血管紧张素转换酶2（ACE 2）的结合来进行感染。除了发热、咳嗽和呼吸急促外，严重的SARS-CoV-2感染病例还可能导致促炎细胞因子的快速过量产生。这种过度活跃的免疫反应被称为细胞因子风暴，它导致几种严重的临床表现，如急性呼吸窘迫综合征和心肌损伤。急性冠状动脉综合征（ACS）和心力衰竭等心血管疾病不仅会在感染开始时加速疾病进展，还会在COVID-19住院患者中出现。来自人类多能干细胞（hPSC）的组织特异性分化细胞和类器官是解决SARS-CoV-2如何损害肺和心脏的极好模型。本文综述了SARS-CoV-2感染的分子基础以及心血管系统与病毒进展之间双向关系的临床前景。此外，我们还讨论了hPSC作为SARS-CoV-2研究和临床转化的动态模型的实用性。
The virus responsible for coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected over 190 million people to date, causing a global pandemic. SARS-CoV-2 relies on binding of its spike glycoprotein to angiotensin-converting enzyme 2 (ACE2) for infection. In addition to fever, cough, and shortness of breath, severe cases of SARS-CoV-2 infection may result in the rapid overproduction of pro-inflammatory cytokines. This overactive immune response is known as a cytokine storm, which leads to several serious clinical manifestations such as acute respiratory distress syndrome and myocardial injury. Cardiovascular disorders such as acute coronary syndrome (ACS) and heart failure not only enhance disease progression at the onset of infection, but also arise in hospitalized patients with COVID-19. Tissue-specific differentiated cells and organoids derived from human pluripotent stem cells (hPSCs) serve as an excellent model to address how SARS-CoV-2 damages the lungs and the heart. In this review, we summarize the molecular basis of SARS-CoV-2 infection and the current clinical perspectives of the bidirectional relationship between the cardiovascular system and viral progression. Furthermore, we also address the utility of hPSCs as a dynamic model for SARS-CoV-2 research and clinical translation.
登录
查看更多内容
洞悉在199介导的急性呼吸衰竭中使用间充质干细胞的使用。
影响因子：
7.2
作者：
Durand N;Mallea J;Zubair AC
通讯作者：
Zubair AC
DOI：
10.1016/j.ahjo.2021.100025
发表时间：
2021-05
期刊：
American heart journal plus : cardiology research and practice
影响因子：
--
作者：
Dixit NM;Churchill A;Nsair A;Hsu JJ
通讯作者：
Hsu JJ
影响因子：
8.8
作者：
Garcia G Jr;Sharma A;Ramaiah A;Sen C;Purkayastha A;Kohn DB;Parcells MS;Beck S;Kim H;Bakowski MA;Kirkpatrick MG;Riva L;Wolff KC;Han B;Yuen C;Ulmert D;Purbey PK;Scumpia P;Beutler N;Rogers TF;Chatterjee AK;Gabriel G;Bartenschlager R;Gomperts B;Svendsen CN;Betz UAK;Damoiseaux RD;Arumugaswami V
通讯作者：
Arumugaswami V
影响因子：
6.1
作者：
Babapoor-Farrokhran, Savalan;Gill, Deanna;Amanullah, Aman
通讯作者：
Amanullah, Aman
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group