Association of Premature Immune Aging and Cytomegalovirus After Solid Organ Transplant.
Association of Premature Immune Aging and Cytomegalovirus After Solid Organ Transplant.
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DOI：
10.3389/fimmu.2021.661551
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发表时间：
2021
影响因子：
7.3
通讯作者：
Maltzman JS
中科院分区：
文献类型：
--
作者：
Higdon LE;Gustafson CE;Ji X;Sahoo MK;Pinsky BA;Margulies KB;Maecker HT;Goronzy J;Maltzman JS
免疫功能随着年龄的增长而改变。巨细胞病毒(CMV)感染加速了与年龄相关的免疫学变化，导致CD8T细胞的寡克隆记忆能力增强，增殖、信号转导和细胞因子产生受损。因此，与同龄的血清CMV阴性(CMV-)的人相比，老年CMV血清阳性(CMV+)的人死亡率更高，对其他感染的反应减弱。巨细胞病毒也是器官移植后的一个重要并发症，最近的研究表明，移植后记忆T细胞的巨细胞病毒相关扩增速度加快。因此，我们结合端粒长度、流式细胞仪表型和单细胞RNA测序，研究了移植后免疫老化是否加速。在CMV+和CMV-受体的一部分中，移植后第一年端粒长度略有下降，CD57+细胞和短端粒之间有很强的一致性。表型老化的细胞在移植后增加，特别是在CMV+的受者中，克隆扩增的T细胞在移植后为终末分化细胞而丰富。总体而言，这些发现证明了CMV+移植受者CD8 T细胞隔间加速老化的模式。
Immune function is altered with increasing age. Infection with cytomegalovirus (CMV) accelerates age-related immunological changes resulting in expanded oligoclonal memory CD8 T cell populations with impaired proliferation, signaling, and cytokine production. As a consequence, elderly CMV seropositive (CMV+) individuals have increased mortality and impaired responses to other infections in comparison to seronegative (CMV–) individuals of the same age. CMV is also a significant complication after organ transplantation, and recent studies have shown that CMV-associated expansion of memory T cells is accelerated after transplantation. Thus, we investigated whether immune aging is accelerated post-transplant, using a combination of telomere length, flow cytometry phenotyping, and single cell RNA sequencing. Telomere length decreased slightly in the first year after transplantation in a subset of both CMV+ and CMV– recipients with a strong concordance between CD57+ cells and short telomeres. Phenotypically aged cells increased post-transplant specifically in CMV+ recipients, and clonally expanded T cells were enriched for terminally differentiated cells post-transplant. Overall, these findings demonstrate a pattern of accelerated aging of the CD8 T cell compartment in CMV+ transplant recipients.
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影响因子：
46.9
作者：
Becht, Etienne;McInnes, Leland;Newell, Evan W.
通讯作者：
Newell, Evan W.
DOI：
10.1038/s41577-019-0180-1
发表时间：
2019-09
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Goronzy JJ;Weyand CM
通讯作者：
Weyand CM
影响因子：
82.9
作者：
Gattinoni L;Speiser DE;Lichterfeld M;Bonini C
通讯作者：
Bonini C
影响因子：
3.1
作者：
Courivaud, Cecile;Bamoulid, Jamal;Ducloux, Didier
通讯作者：
Ducloux, Didier
影响因子：
13.6
作者：
Bottomley, Matthew J.;Harden, Paul N.;Wood, Kathryn J.
通讯作者：
Wood, Kathryn J.