Rfam 13.0: shifting to a genome-centric resource for non-coding RNA families.

Rfam 13.0: shifting to a genome-centric resource for non-coding RNA families.
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DOI:
10.1093/nar/gkx1038
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发表时间:
2018-01-04
影响因子:
14.9
通讯作者:
Petrov AI
Petrov AI
中科院分区:
生物学2区
文献类型:
--
作者:
Kalvari I;Argasinska J;Quinones-Olvera N;Nawrocki EP;Rivas E;Eddy SR;Bateman A;Finn RD;Petrov AI

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Rfam数据库是RNA家族的集合,其中每个家族由多序列比对、共有二级结构和协方差模型表示。在本文中,我们介绍Rfam 13.0版,它切换到一个新的基因组为中心的方法,注释一个非冗余的参考基因组与RNA家族。我们描述了新的Web界面功能,包括多面文本搜索和R-scape二级结构可视化。我们讨论了一个新的文献策展工作流程和一个基于RNAcentral构建家庭的管道。13.0版新增236个家庭,家庭总数达到2687个。Rfam的网站是http://rfam.org。
The Rfam database is a collection of RNA families in which each family is represented by a multiple sequence alignment, a consensus secondary structure, and a covariance model. In this paper we introduce Rfam release 13.0, which switches to a new genome-centric approach that annotates a non-redundant set of reference genomes with RNA families. We describe new web interface features including faceted text search and R-scape secondary structure visualizations. We discuss a new literature curation workflow and a pipeline for building families based on RNAcentral. There are 236 new families in release 13.0, bringing the total number of families to 2687. The Rfam website is http://rfam.org.
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