Subclinical Anxiety and Posttraumatic Stress Influence Cortical Thinning During Adolescence.
Subclinical Anxiety and Posttraumatic Stress Influence Cortical Thinning During Adolescence.
复制标题
亚临床焦虑和创伤后应激会影响青春期皮质稀疏。
DOI：
10.1016/j.jaac.2020.11.020
复制
发表时间：
2021-10
影响因子：
13.3
通讯作者：
Wilson TW
中科院分区：
文献类型：
--
作者：
Taylor BK;Eastman JA;Frenzel MR;Embury CM;Wang YP;Stephen JM;Calhoun VD;Badura-Brack AS;Wilson TW
青春期是焦虑和情绪障碍发展和出现的敏感时期。研究表明，从亚临床到临床水平的症状与新皮层的病理发育变化有关。然而，这些研究大多是横向的，限制了该领域识别这些症状对神经发育影响的能力。本研究考察了早期报告的症状如何预测基线皮质厚度和表面积，以及这些指标在青春期的变化轨迹。205名发育正常的9至15岁儿童（103名男性参与者）在三年内每年完成3T结构MRI。从这些数据中，我们提取了每年的平均皮质厚度和总表面积。青年自我报告他们的焦虑，抑郁，和创伤后应激症状在他们的第一次访问。我们采用潜在生长曲线模型来确定这些症状以及性别相互作用如何预测基线厚度和表面积，以及三年内这些测量值的变化率。随着时间的推移，较高的焦虑与较低的基线厚度和缓慢的皮质变薄有关。相反，更大的创伤后压力预示着更高的基线厚度和随着时间的推移加速变薄。性别互动表明，与男性参与者相比，女性参与者的影响有所减弱。抑郁症状与皮质厚度或表面积无关。女性青少年可能表现出更多的区域特异性症状组对皮质厚度的影响，尽管这需要进一步的研究。男性青少年的皮质厚度似乎更容易受到焦虑和创伤后应激症状的影响，表现出多年来的整体变化。
Adolescence is a sensitive period for the development and emergence of anxiety and mood disorders. Research suggests that symptoms ranging from subclinical to clinical levels are associated with pathological developmental changes in the neocortex. However, much of this research has been cross-sectional, limiting the field’s ability to identify the neurodevelopmental impacts of these symptoms. The present study examined how early reported symptoms predict baseline cortical thickness and surface area, and trajectories of change in these measures during adolescence. 205 typically-developing 9- to 15-year-olds (103 male participants) completed 3T structural MRI annually for three years. From these, we extracted mean cortical thickness and total surface area for each year. Youth self-reported their anxiety, depressive, and posttraumatic stress symptoms during their first visit. We employed latent growth curve modeling to determine how these symptoms along with sex interactions predicted baseline thickness and surface area, and rates of change in these measures over the three-year period. Higher anxiety was associated with lower baseline thickness and slowed cortical thinning over time. Conversely, greater posttraumatic stress predicted higher baseline thickness and accelerated thinning over time. Sex interactions suggested that the effects were dampened among female compared to male participants. Depressive symptoms were not related to cortical thickness or surface area. Female adolescents may express more regionally specific effects of symptoms sets on cortical thickness, though this requires further investigation. Cortical thickness in male adolescents appears to be preferentially susceptible to anxiety and posttraumatic stress symptoms, exhibiting global changes across multiple years.
登录
查看更多内容
DOI：
10.1080/10705519909540118
发表时间：
1999-01-01
影响因子：
6
作者：
Hu, Li-tze;Bentler, Peter M.
通讯作者：
Bentler, Peter M.
影响因子：
11.3
作者：
Herringa R;Phillips M;Almeida J;Insana S;Germain A
通讯作者：
Germain A
影响因子：
6.6
作者：
Besteher, Bianca;Gaser, Christian;Nenadic, Igor
通讯作者：
Nenadic, Igor
DOI：
10.1111/jcpp.12895
发表时间：
2018-09
期刊：
Journal of child psychology and psychiatry, and allied disciplines
影响因子：
--
作者：
Bos MGN;Peters S;van de Kamp FC;Crone EA;Tamnes CK
通讯作者：
Tamnes CK
影响因子：
3.2
作者：
Franz, Carol E.;Hatton, Sean N.;Kremen, William S.
通讯作者：
Kremen, William S.