The role of fundus autofluorescence in late-onset retinitis pigmentosa (LORP) diagnosis.
The role of fundus autofluorescence in late-onset retinitis pigmentosa (LORP) diagnosis.
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DOI：
10.3109/13816810.2013.800891
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发表时间：
2014-09
影响因子：
1.2
通讯作者：
Tsang SH
中科院分区：
文献类型：
--
作者：
Lee TJ;Hwang JC;Chen RW;Lima LH;Wang NK;Tosi J;Freund KB;Yannuzzi LA;Tsang SH
目的：探讨眼底自体荧光检查在迟发性视网膜色素变性诊断中的价值和特点。观察性案例系列。对被诊断为迟发性视网膜色素变性的患者在机构中进行了回顾性研究。对6名患者的12只眼进行了鉴定，并复习了病历。所有患者都表现为缓慢进行性的外周视野丧失，最初的临床检查显示只有轻微的视网膜改变。所有患者都明显缺乏视网膜内色素的迁移。六分之五的患者接受了脑部磁共振成像，以排除颅内过程，所有患者都是从另一位眼科医生那里转诊进行进一步评估的。所有患者最终都使用了眼底自发荧光，并显示了比最初临床检查所认识的更广泛的视网膜病理。所有病例的眼底自发荧光检查都指向视网膜病因学，并通过视网膜电波测试最终诊断为迟发性视网膜色素变性。在迟发性视网膜色素变性患者中，眼底自发荧光可能比立体眼底生物显微镜检查更敏感。早期使用眼底自发荧光成像来评估有微小视网膜病变和主诉周围视野丧失的患者，可能是及时和经济有效的诊断的有效策略。
To demonstrate the utility and characteristics of fundus autofluorescence in late-onset retinitis pigmentosa. Observational case series. Patients diagnosed with late-onset retinitis pigmentosa were identified retrospectively in an institutional setting. Twelve eyes of six patients were identified and medical records were reviewed. All patients presented with slowly progressive peripheral field loss and initial clinical examination revealed only subtle retinal changes. There was a notable lack of intraretinal pigment migration in all patients. Five out of six patients underwent magnetic resonance imaging of the brain to rule out intracranial processes and all were referred from another ophthalmologist for further evaluation. Fundus autofluorescence was ultimately employed in all patients and revealed more extensive retinal pathology than initially appreciated on clinical examination. Fundus autofluorescence directed the workup toward a retinal etiology in all cases and led to the eventual diagnosis of late-onset retinitis pigmentosa through electroretinogram testing. Fundus autofluorescence may be a more sensitive marker for retinal pathology than stereo fundus biomicroscopy alone in late-onset retinitis pigmentosa. Early use of fundus autofluorescence imaging in the evaluation of patients with subtle retinal lesions and complaints of peripheral field loss may be an effective strategy for timely and cost-efficient diagnosis.
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影响因子：
3.4
作者：
Berson, Eliot L.
通讯作者：
Berson, Eliot L.
影响因子：
3.5
作者：
Han, Meng;Giese, Guenter;Niemz, Markolf H.
通讯作者：
Niemz, Markolf H.
影响因子：
2
作者：
Tsui, Irena;Chou, Chai;Tsang, Stephen H.
通讯作者：
Tsang, Stephen H.
DOI：
10.1007/s00417-005-1186-x
发表时间：
2005-10-01
影响因子：
2.7
作者：
Popovic, P;Jarc-Vidmar, M;Hawlina, M
通讯作者：
Hawlina, M
DOI：
10.1097/iae.0b013e3181ac2418
发表时间：
2009-07
期刊：
Retina (Philadelphia, Pa.)
影响因子：
--
作者：
Lima LH;Cella W;Greenstein VC;Wang NK;Busuioc M;Smith RT;Yannuzzi LA;Tsang SH
通讯作者：
Tsang SH