Determination and significance of a new carbohydrate antigen CA19-9 in digestive system cancers.
Determination and significance of a new carbohydrate antigen CA19-9 in digestive system cancers.
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新碳水化合物抗原CA19-9在消化系统癌症中的测定及其意义。
DOI：
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
K. Morita
中科院分区：
文献类型：
--
作者：
Y. Arakawa;H. Ariga;M. Kano;Y. Matsuo;T. Honda;K. Morita
为探讨CA19-9的诊断意义，采用放射免疫法测定225例健康人、201例癌症患者、423例良性疾病患者和21例孕妇的血清CA19-9水平。正常人血清CA19-9平均水平为11.2+/-0.4U/ml(范围6-100U/ml)。293例消化系统非肿瘤性疾病患者血清CA19-9水平高于37U/ml者占7.9%。消化系统肿瘤中，食道癌11例，胃癌68例，结直肠癌23例，原发性肝癌18例，胆道癌35例，胰腺癌20例，分别为18.2%、42.7%、39.1%、27.8%、71.4%、75%。血药浓度>100U/ml的患者多为癌性疾病。CA19-9在I、II、III期胃癌和结直肠癌患者中的阳性率极低，而在IV期和复发癌患者中，CA19-9的阳性率和浓度有迅速上升的趋势。CA19-9、CEA和铁蛋白联合检测，与CA19-9单独检测的阳性率相比，在胃癌、结直肠癌和胆道癌中的阳性率分别提高到42.7%、39.1%和71.4%，提示联合检测这些肿瘤标志物有助于提高其临床应用价值。
To assess the diagnostic significance of CA19-9, the serum levels in 225 healthy subjects, 201 patients with cancers, 423 patients with benign diseases and 21 pregnant women, were determined by RIA. The mean CA19-9 level of the healthy subjects was 11.2 +/- 0.4 U/ml (range, 6-100 U/ml). Only 3.1% of them were above 37 U/ml. The CA19-9 levels were elevated above 37 U/ml in 7.9% of 293 patients with non-carcinomatous diseases of the digestive system. Among digestive system cancers, elevated levels were found in 18.2% of 11 patients with esophageal cancer, 42.7% of 68 patients with gastric cancer, 39.1% of 23 patients with colorectal cancer, 27.8% of 18 patients with primary hepatic cancer, 71.4% of 35 patients with biliary cancer, and 75% of 20 patients with pancreatic cancer. Most of the patients with levels above 100 U/ml had carcinomatous diseases. The CA19-9 positive rates for patients with gastric cancer and colorectal cancer were extremely low at stages I, II and III, while in patients at stage IV and in patients with recurrent cancer, a tendency for rapid increase in the positive rates and concentrations of CA19-9 was noted. Based on combination assay of CA19-9, CEA and ferritin, in comparison with the positive rates for CA19-9 alone, it was found that the rates were raised to 42.7% in gastric cancer, to 39.1% in colorectal cancer, and to 71.4% in biliary cancer, suggesting the simultaneous determination with these tumor markers may serve to elevate their usefulness.
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DOI：
10.1016/s0021-9258(19)45389-1
发表时间：
1982-12
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
John L. MagnaniS;Bo Nilssong;Manfred BrockhausSV;David Zopfl;Zenon SteplewskiJI;Hilary Koprowskill;V. Ginsburg
通讯作者：
John L. MagnaniS;Bo Nilssong;Manfred BrockhausSV;David Zopfl;Zenon SteplewskiJI;Hilary Koprowskill;V. Ginsburg
影响因子：
56.9
作者：
KOPROWSKI, H;HERLYN, M;SEARS, HF
通讯作者：
SEARS, HF
人结直肠癌和黑色素瘤细胞释放单克隆抗体定义的抗原。
影响因子：
11.2
作者：
Steplewski,Z;Chang,TH;Herlyn,M;Koprowski,H
通讯作者：
Koprowski,H
免疫过氧化物酶测定中胃肠癌相关抗原。
影响因子：
11.2
作者：
Atkinson,BF;Ernst,CS;Herlyn,M;Steplewski,Z;Sears,HF;Koprowski,H
通讯作者：
Koprowski,H