Prevalence of Neuropsychiatric Symptoms across the Declining Memory Continuum: An Observational Study in a Memory Clinic Setting.
Prevalence of Neuropsychiatric Symptoms across the Declining Memory Continuum: An Observational Study in a Memory Clinic Setting.
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记忆衰退连续体中神经精神症状的患病率：记忆诊所环境中的观察性研究
DOI：
10.1159/000338410
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发表时间：
2012-01
影响因子：
2.3
通讯作者：
Yu X
中科院分区：
文献类型：
--
作者：
Zhang M;Wang H;Li T;Yu X
本研究旨在比较从正常衰老、主观认知障碍(SCI)和轻度认知障碍(MCI)到阿尔茨海默病(AD)的记忆衰退连续体中神经精神症状(NPS)的出现频率，并探讨NPS的临床相关性。在记忆诊所，157名受试者(46名轻度AD患者、38名MCI患者、24名SCI患者和49名正常对照)完成了神经行为测试。每个领域的临床意义被定义为条目得分≥4。结果：临床显著抑郁在脊髓损伤组比正常对照组更常见(p<；005)。与其他组相比，轻度AD组的NPS频率显著增加。临床上明显的冷漠和异常运动行为在AD组中比MCI组更常见(p<；0.05)。MMSE评分(OR4.84，95%CI1.92~12.16，p=0.001)和淡漠(OR12.73，95%CI1.48~109.68，p=0.021)显著决定轻度AD的诊断状态。在整个记忆力下降的连续体中，NPS的频率在轻度AD患者中最高。抑郁、冷漠和异常的运动行为应该得到更多的关注。冷漠可能是轻度阿尔茨海默病的独立决定因素。
The study aimed to compare the frequency of neuropsychiatric symptoms (NPS) across the declining memory continuum, from normal aging, subjective cognitive impairment (SCI), and mild cognitive impairment (MCI) to Alzheimer's disease (AD), and to explore the clinical correlates of NPS. In a memory clinic, 157 subjects (46 mild AD patients, 38 MCI individuals, 24 SCI subjects, and 49 normal controls) completed the neurobehavioral assessments with the Neuropsychiatric Inventory (NPI). The clinical significance of each NPI domain was defined as an item score ≥4. Result: Clinically significant depression was more common in the SCI than in the normal control group (p < 0.05). The frequency of NPS was significantly greater in the mild AD group compared to other groups. Clinically significant apathy and aberrant motor behavior were more common among the AD group than the MCI group (p < 0.05). The MMSE score (OR 4.84, 95% CI 1.92–12.16, p = 0.001) and apathy (OR 12.73, 95% CI 1.48–109.68, p = 0.021) significantly determined the diagnostic status as MCI or mild AD. Across the declining memory continuum, the frequency of NPS was highest among mild AD patients. Depression, apathy, and aberrant motor behavior deserve more attention. Presence of apathy might be an independent determinant for mild AD.
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影响因子：
5.7
作者：
GAGNON, M;DARTIGUES, JF;BARBERGERGATEAU, P
通讯作者：
BARBERGERGATEAU, P
影响因子：
2.1
作者：
Hwang, TJ;Masterman, DL;Cummings, JL
通讯作者：
Cummings, JL
影响因子：
7.2
作者：
Chan, Wai-Chi;Lam, Linda Chiu-Wa;Chiu, Helen Fung-Kum
通讯作者：
Chiu, Helen Fung-Kum
影响因子：
2.4
作者：
Piccininni, M;Di Carlo, A;Inzitari, D
通讯作者：
Inzitari, D
影响因子：
7.2
作者：
Edell, WS;Tunis, SL
通讯作者：
Tunis, SL