Does cannabidiol make cannabis safer? A randomised, double-blind, cross-over trial of cannabis with four different CBD:THC ratios.
Does cannabidiol make cannabis safer? A randomised, double-blind, cross-over trial of cannabis with four different CBD:THC ratios.
复制标题
DOI：
10.1038/s41386-022-01478-z
复制
发表时间：
2023-05
影响因子：
7.6
通讯作者：
McGuire, Philip
中科院分区：
文献类型：
--
作者：
Englund, Amir;Oliver, Dominic;Chesney, Edward;Chester, Lucy;Wilson, Jack;Sovi, Simina;De Micheli, Andrea;Hodsoll, John;Fusar-Poli, Paolo;Strang, John;Murray, Robin M.;Freeman, Tom P.;McGuire, Philip
随着各国采取更加宽松的大麻政策，确定可减少大麻使用有害影响的战略变得越来越重要。这项研究旨在确定增加大麻的CBD含量是否可以减少其有害影响。46名健康的、不经常使用大麻的人参加了一项双盲、受试者内、随机试验，试验中大麻制剂的CBD含量各不相同。有一个初始基线访问，然后是四个药物管理访问，其中参与者吸入含有10 mg THC和0 mg（0：1 CBD：THC），10 mg（1：1），20 mg（2：1）或30 mg（3：1）CBD的汽化大麻，以随机，平衡的顺序。主要结果是霍普金斯言语学习任务中延迟言语回忆的变化。次要结局包括精神病症状严重程度的变化（例如，阳性和阴性症状量表[PANSS]阳性子量表），加上进一步的认知、主观、愉悦、药理学和生理学效应。测量THC和CBD的系列血浆浓度。THC（0：1）与延迟言语回忆受损（t（45）= 3.399，d = 0.50，p = 0.001）和PANSS阳性精神病症状相关（t（45）=-4.709，d = 0.69，p = 2.41 × 10-5）。这些作用没有受到任何剂量的CBD的显著调节。此外，没有证据表明CBD调节THC对其他认知，精神病，主观，愉悦和生理措施的影响。CBD剂量与血浆CBD浓度之间存在剂量-反应关系，对血浆THC浓度无影响。在药用和娱乐大麻产品中最常见的CBD：THC比率中，我们没有发现CBD可以防止大麻的急性不良反应的证据。在关于药用和娱乐大麻的卫生政策和安全决定中应考虑到这一点。
As countries adopt more permissive cannabis policies, it is increasingly important to identify strategies that can reduce the harmful effects of cannabis use. This study aimed to determine if increasing the CBD content of cannabis can reduce its harmful effects. Forty-six healthy, infrequent cannabis users participated in a double-blind, within-subject, randomised trial of cannabis preparations varying in CBD content. There was an initial baseline visit followed by four drug administration visits, in which participants inhaled vaporised cannabis containing 10 mg THC and either 0 mg (0:1 CBD:THC), 10 mg (1:1), 20 mg (2:1), or 30 mg (3:1) CBD, in a randomised, counter-balanced order. The primary outcome was change in delayed verbal recall on the Hopkins Verbal Learning Task. Secondary outcomes included change in severity of psychotic symptoms (e.g., Positive and Negative Syndrome Scale [PANSS] positive subscale), plus further cognitive, subjective, pleasurable, pharmacological and physiological effects. Serial plasma concentrations of THC and CBD were measured. THC (0:1) was associated with impaired delayed verbal recall (t(45) = 3.399, d = 0.50, p = 0.001) and induced positive psychotic symptoms on the PANSS (t(45) = −4.709, d = 0.69, p = 2.41 × 10–5). These effects were not significantly modulated by any dose of CBD. Furthermore, there was no evidence of CBD modulating the effects of THC on other cognitive, psychotic, subjective, pleasurable, and physiological measures. There was a dose-response relationship between CBD dose and plasma CBD concentration, with no effect on plasma THC concentrations. At CBD:THC ratios most common in medicinal and recreational cannabis products, we found no evidence that CBD protects against the acute adverse effects of cannabis. This should be considered in health policy and safety decisions about medicinal and recreational cannabis.
登录
查看更多内容
DOI：
10.1016/s2215-0366(19)30048-3
发表时间：
2019-05
期刊：
The lancet. Psychiatry
影响因子：
--
作者：
Di Forti M;Quattrone D;Freeman TP;Tripoli G;Gayer-Anderson C;Quigley H;Rodriguez V;Jongsma HE;Ferraro L;La Cascia C;La Barbera D;Tarricone I;Berardi D;Szöke A;Arango C;Tortelli A;Velthorst E;Bernardo M;Del-Ben CM;Menezes PR;Selten JP;Jones PB;Kirkbride JB;Rutten BP;de Haan L;Sham PC;van Os J;Lewis CM;Lynskey M;Morgan C;Murray RM;EU-GEI WP2 Group
通讯作者：
EU-GEI WP2 Group
影响因子：
3.4
作者：
Arkell, Thomas R.;Lintzeris, Nicholas;McGregor, Iain S.
通讯作者：
McGregor, Iain S.
影响因子：
6
作者：
Freeman, Tom P.;Lorenzetti, Valentina
通讯作者：
Lorenzetti, Valentina
影响因子：
4.1
作者：
Englund, Amir;Morrison, Paul D.;Kapur, Shitij
通讯作者：
Kapur, Shitij
影响因子：
3.4
作者：
Lawn, Will;Freeman, Tom P.;Curran, H. Valerie
通讯作者：
Curran, H. Valerie