Measurement of bone marrow lesions by MR imaging in knee osteoarthritis using quantitative segmentation methods--a reliability and sensitivity to change analysis.
Measurement of bone marrow lesions by MR imaging in knee osteoarthritis using quantitative segmentation methods--a reliability and sensitivity to change analysis.
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DOI：
10.1186/1471-2474-15-447
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发表时间：
2014-12-20
影响因子：
2.3
通讯作者：
Jurik AG
中科院分区：
文献类型：
--
作者：
Nielsen FK;Egund N;Peters D;Jurik AG
MRI对膝骨关节炎（KOA）骨髓病变（BMLs）的纵向评估通常采用半定量分级方法。定量分割方法可能对检测随时间的变化更敏感。本研究的目的是评价和比较两种定量MR分割方法的有效性和灵敏度，一种计算机辅助（CAS）和一种手动（MS）方法测定KOA中bml的变化。22例局限于股胫间室内侧的KOA患者在基线和随访时（中间间隔334天）进行了MRI检查。使用1.5 T系统获得STIR、T1和脂肪饱和T1对比后序列。44个矢状面STIR序列由两个阅读器独立评估以定量BML。以股骨外侧髁和胫骨平台正常骨髓信号强度（si）作为阈值。在股骨内侧髁和胫骨平台处测量SIs超过阈值（BML）的骨髓体积，并与髁/平台的总体积相关。95%的基线一致性界限用于确定对变化的敏感性。CAS和MS的平均阈值几乎相同，但绝对和相对BML体积在股骨分别为1319 mm3/10%和1828 mm3/15%，在胫骨分别为941 mm3/7%和2097 mm3/18%。CAS与MS测量的BML体积呈显著相关，但测量的组织变化存在差异。超过阈值的体素体积由CAS测量，而MS包括具有正常SI的中间体素。CAS的95%一致性范围小于MS；CAS对相对BML的显著变化超出了-2.0% ~ 4.7%的范围，而MS的变化范围为-6.9% ~ 8.2%。使用CAS的13个膝关节和使用ms的10个膝关节的BML发生了显著变化，CAS是测量BML的可靠方法，对随时间变化的检测比ms更敏感。两种方法测量的BML体积不同，但显著相关。本文的在线版本（doi:10.1186/1471-2474-15-447）包含补充材料，可供授权用户使用。
Longitudinal assessment of bone marrow lesions (BMLs) in knee osteoarthritis (KOA) by MRI is usually performed using semi-quantitative grading methods. Quantitative segmentation methods may be more sensitive to detect change over time. The purpose of this study was to evaluate and compare the validity and sensitivity to detect changes of two quantitative MR segmentation methods for measuring BMLs in KOA, one computer assisted (CAS) and one manual (MS) method. Twenty-two patients with KOA confined to the medial femoro-tibial compartment obtained MRI at baseline and follow-up (median 334 days in between). STIR, T1 and fat saturated T1 post-contrast sequences were obtained using a 1.5 T system. The 44 sagittal STIR sequences were assessed independently by two readers for quantification of BML. The signal intensities (SIs) of the normal bone marrow in the lateral femoral condyles and tibial plateaus were used as threshold values. The volume of bone marrow with SIs exceeding the threshold values (BML) was measured in the medial femoral condyle and tibial plateau and related to the total volume of the condyles/plateaus. The 95% limits of agreement at baseline were used to determine the sensitivity to change. The mean threshold values of CAS and MS were almost identical but the absolute and relative BML volumes differed being 1319 mm3/10% and 1828 mm3/15% in the femur and 941 mm3/7% and 2097 mm3/18% in the tibia using CAS and MS, respectively. The BML volumes obtained by CAS and MS were significantly correlated but the tissue changes measured were different. The volume of voxels exceeding the threshold values was measured by CAS whereas MS included intervening voxels with normal SI. The 95% limits of agreement were narrower by CAS than by MS; a significant change of relative BML by CAS was outside the limits of -2.0%-4.7% whereas the limits by MS were -6.9%-8.2%. The BML changed significantly in 13 knees using CAS and in 10 knees by MS. CAS was a reliable method for measuring BML and more sensitive to detect changes over time than MS. The BML volumes measured by the two methods differed but were significantly correlated. The online version of this article (doi:10.1186/1471-2474-15-447) contains supplementary material, which is available to authorized users.
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影响因子：
27.4
作者：
Jorgensen, Anette;Stengaard-Pedersen, Kristian;Frimer-Larsen, Helle
通讯作者：
Frimer-Larsen, Helle
影响因子：
5
作者：
Mobasheri, A.
通讯作者：
Mobasheri, A.
影响因子：
7
作者：
Felson, D. T.;Parkes, M. J.;Hutchinson, C. E.
通讯作者：
Hutchinson, C. E.
影响因子：
4.7
作者：
Kothari, Ami;Guermazi, Ali;Chmiel, Joan S.;Dunlop, Dorothy;Song, Jing;Almagor, Orit;Marshall, Meredith;Cahue, September;Prasad, Pottumarthi;Sharma, Leena
通讯作者：
Sharma, Leena
影响因子：
--
作者：
Lawrence, Reva C.;Felson, David T.;Wolfe, Frederick
通讯作者：
Wolfe, Frederick