Defining the human microbiome.

Defining the human microbiome.
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DOI:
10.1111/j.1753-4887.2012.00493.x
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发表时间:
2012-08
期刊:
影响因子:
6.1
通讯作者:
Knight R
Knight R
中科院分区:
医学2区
文献类型:
--
作者:
Ursell LK;Metcalf JL;Parfrey LW;Knight R

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快速发展的测序方法和分析技术正在增强我们了解人类微生物组的能力,以及我们如何定义微生物组及其组成。在这篇综述中,我们强调了最近的研究,这些研究扩展了我们在不同的空间和时间尺度上理解人类微生物组的能力,包括跨越数月的每日时间序列数据集。此外,我们讨论了新出现的概念,定义业务分类单位,多样性指数,核心与瞬时微生物组和肠型的可能性。测序技术和我们对微生物组的理解的其他进展将为利用微生物群进行个性化医疗提供令人兴奋的前景。
Rapidly developing sequencing methods and analytical techniques are enhancing our ability to understand the human microbiome, and, indeed, how we define the microbiome and its constituents. In this review we highlight recent research that expands our ability to understand the human microbiome on different spatial and temporal scales, including daily timeseries datasets spanning months. Furthermore, we discuss emerging concepts related to defining operational taxonomic units, diversity indices, core versus transient microbiomes and the possibility of enterotypes. Additional advances in sequencing technology and in our understanding of the microbiome will provide exciting prospects for exploiting the microbiota for personalized medicine.
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