MicroRNAs: New Players in the Pathobiology of Preeclampsia.
MicroRNAs: New Players in the Pathobiology of Preeclampsia.
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DOI：
10.3389/fcvm.2017.00060
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发表时间：
2017
影响因子：
3.6
通讯作者：
Chatterjee P
中科院分区：
文献类型：
--
作者：
Bounds KR;Chiasson VL;Pan LJ;Gupta S;Chatterjee P
多年来，我们对microRNAs（miRNAs）如何调节基因网络并影响导致各种人类病理学的不同分子途径的理解已显着提高。相反，miRNAs在妊娠相关高血压疾病如先兆子痫（PE）中的作用才刚刚开始出现。最近的论文强调，不良妊娠结局与几种miRNAs的异常表达有关。目前，正在努力确定这些胎盘miRNAs的生物学功能，这可以揭示它们对这些妊娠相关疾病的贡献。发现miRNA在循环中是稳定的，再加上胎盘能够将它们释放到外泌体中的循环中，这一发现产生了将它们用作生物标志物的热情。在这篇综述中，我们将总结我们的理解与PE，妊娠高血压疾病的miRNA调控的最新研究结果。将特别强调关键miRNA分子如miR-210和miR-155的作用，这些分子已知在PE女性中持续失调。
Our understanding of how microRNAs (miRNAs) regulate gene networks and affect different molecular pathways leading to various human pathologies has significantly improved over the years. In contrary, the role of miRNAs in pregnancy-related hypertensive disorders such as preeclampsia (PE) is only beginning to emerge. Recent papers highlight that adverse pregnancy outcomes are associated with aberrant expression of several miRNAs. Presently, efforts are underway to determine the biologic function of these placental miRNAs which can shed light on their contribution to these pregnancy-related disease conditions. The discovery that miRNAs are stable in circulation coupled with the fact that the placenta is capable of releasing them to the circulation in exosomes generates a lot of enthusiasm to use them as biomarkers. In this review, we will summarize the recent findings of our understanding of miRNA regulation in relation to PE, a hypertensive disorder of pregnancy. Particular emphasis will be given to the role of key miRNA molecules such as miR-210 and miR-155 that are known to be consistently dysregulated in women with PE.
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影响因子：
4.6
作者：
Hromadnikova I;Kotlabova K;Ondrackova M;Kestlerova A;Novotna V;Hympanova L;Doucha J;Krofta L
通讯作者：
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影响因子：
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作者：
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DOI：
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发表时间：
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影响因子：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1016/j.biocel.2015.08.018
发表时间：
2015-11-01
影响因子：
4
作者：
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通讯作者：
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