Circulating C19MC microRNAs in preeclampsia, gestational hypertension, and fetal growth restriction.
Circulating C19MC microRNAs in preeclampsia, gestational hypertension, and fetal growth restriction.
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DOI：
10.1155/2013/186041
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发表时间：
2013
影响因子：
4.6
通讯作者：
Krofta L
中科院分区：
文献类型：
--
作者：
Hromadnikova I;Kotlabova K;Ondrackova M;Kestlerova A;Novotna V;Hympanova L;Doucha J;Krofta L
本研究的目的是鉴定已确诊先兆子痫（n = 63）、胎儿生长受限（n = 27）和妊娠期高血压（n = 23）患者中循环C19 MC microRNA（miR-516- 5 p、miR-517 β、miR-518 b、miR-520 a β、miR-520 h、miR-525和miR-526 a）的谱。我们研究了血浆浓度和microRNA表达水平与疾病严重程度之间的相关性，包括临床体征、分娩要求和多普勒超声参数。使用绝对和相对定量方法，增加细胞外C19 MC microRNA水平，（miR-516-5p，P = 0.037，P = 0.009; miR-517 - 5p，P = 0.033，P = 0.043; miR-520 α-β，P = 0.001，P = 0.009; miR-525，P = 0.026，P = 0.01; miR-526 a，P = 0.03，P = 0.035）在子痫前期患者中的表达。相关性分析指出C19 MC microRNA血浆浓度和表达谱之间没有关系，并确定了围产期结局较差的风险因素。然而，血浆C19 MC microRNA水平与大脑中动脉搏动指数和胎盘/胎盘比值之间存在相关性。这项研究带来了一个有趣的发现，即miR-516- 5 p、miR-517 β、miR-520 α、miR-525和miR-526 α的上调是先兆子痫的特征性现象。
The objective of the study was to identify the profile of circulating C19MC microRNAs (miR-516-5p, miR-517∗, miR-518b, miR-520a∗, miR-520h, miR-525, and miR-526a) in patients with established preeclampsia (n = 63), fetal growth restriction (n = 27), and gestational hypertension (n = 23). We examined the correlation between plasmatic concentrations and expression levels of microRNAs and the severity of the disease with respect to clinical signs, requirements for the delivery, and Doppler ultrasound parameters. Using absolute and relative quantification approaches, increased extracellular C19MC microRNA levels (miR-516-5p, P = 0.037, P = 0.009; miR-517∗, P = 0.033, P = 0.043; miR-520a∗, P = 0.001, P = 0.009; miR-525, P = 0.026, P = 0.01; miR-526a, P = 0.03, P = 0.035) were detected in patients with preeclampsia. The association analysis pointed to no relationship between C19MC microRNA plasmatic concentrations and expression profile and identified risk factors for a poorer perinatal outcome. However, the dependence between the levels of plasmatic C19MC microRNAs and the pulsatility index in the middle cerebral artery and the values of cerebroplacental ratio was demonstrated. The study brought the interesting finding that the upregulation of miR-516-5p, miR-517∗, miR-520a∗, miR-525, and miR-526a is a characteristic phenomenon of established preeclampsia.
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影响因子：
9.3
作者：
Chan, K. C. Allen;Ding, Chunming;Lo, Y. M. Dennis
通讯作者：
Lo, Y. M. Dennis
影响因子：
30.8
作者：
Bentwich, I;Avniel, A;Bentwich, Z
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Bentwich, Z
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作者：
Hromadnikova, Ilona
通讯作者：
Hromadnikova, Ilona
影响因子：
3.4
作者：
Kotlabova, Katerina;Doucha, Jindrich;Hromadnikova, Ilona
通讯作者：
Hromadnikova, Ilona
影响因子：
0.4
作者：
Gunel, T.;Zeybek, Y. G.;Aydinli, K.
通讯作者：
Aydinli, K.