Patterns of homozygosity in insular and continental goat breeds.
Patterns of homozygosity in insular and continental goat breeds.
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DOI：
10.1186/s12711-018-0425-7
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发表时间：
2018-11-19
期刊：
影响因子：
--
通讯作者：
AdaptMap Consortium
中科院分区：
文献类型：
--
作者：
Cardoso TF;Amills M;Bertolini F;Rothschild M;Marras G;Boink G;Jordana J;Capote J;Carolan S;Hallsson JH;Kantanen J;Pons A;Lenstra JA;AdaptMap Consortium
品种的基因隔离可能会导致多样性的显着丧失，并对健康和性能产生影响。在这项研究中，我们使用山羊 SNP50 BeadChip 对来自 25 个欧洲和非洲品种的 480 个个体进行基因分型，并比较了岛屿和附近大陆品种的纯合性模式，研究了地理隔离对山羊遗传多样性模式的影响。在分析的品种中，ROH 的数量和总长度差异很大，并且根据品种的不同，ROH 可以覆盖基因组的很大一部分（冰岛山羊可达 1.6 Gb）。与大陆山羊相比，来自冰岛、马达加斯加、拉帕尔马和爱尔兰（Bilberry 和 Arran）的山羊的 ROH 覆盖度、ROH 数量和 FROH 值显着增加（P 值 < 0.05）。来自地中海岛屿的山羊代表了一个更复杂的情况，因为某些群体表现出纯合性水平显着增加（例如吉尔根塔纳），而其他群体则没有（例如科西嘉岛和萨尔达）。岛屿山羊种群 ROH 的数量和总长度与岛屿和最近的大陆位置之间的距离的相关性揭示了极长的距离对纯合性模式的影响。这些结果表明，岛化对纯合性模式的影响是可变的。在马达加斯加、冰岛、爱尔兰（越橘和阿伦）和拉帕尔马饲养的山羊表现出高水平的纯合性，而在地中海岛屿饲养的山羊则显示出与大陆种群相似的纯合性模式。这些结果表明，岛屿山羊种群的多样性受到地理分布、种群规模、人口历史、贸易和品种管理等多种因素的调节。本文的在线版本 (10.1186/s12711-018-0425-7) 包含补充材料，可供授权用户使用。
Genetic isolation of breeds may result in a significant loss of diversity and have consequences on health and performance. In this study, we examined the effect of geographic isolation on caprine genetic diversity patterns by genotyping 480 individuals from 25 European and African breeds with the Goat SNP50 BeadChip and comparing patterns of homozygosity of insular and nearby continental breeds. Among the breeds analysed, number and total length of ROH varied considerably and depending on breeds, ROH could cover a substantial fraction of the genome (up to 1.6 Gb in Icelandic goats). When compared with their continental counterparts, goats from Iceland, Madagascar, La Palma and Ireland (Bilberry and Arran) displayed a significant increase in ROH coverage, ROH number and FROH values (P value < 0.05). Goats from Mediterranean islands represent a more complex case because certain populations displayed a significantly increased level of homozygosity (e.g. Girgentana) and others did not (e.g. Corse and Sarda). Correlations of number and total length of ROH for insular goat populations with the distance between islands and the nearest continental locations revealed an effect of extremely long distances on the patterns of homozygosity. These results indicate that the effects of insularization on the patterns of homozygosity are variable. Goats raised in Madagascar, Iceland, Ireland (Bilberry and Arran) and La Palma, show high levels of homozygosity, whereas those bred in Mediterranean islands display patterns of homozygosity that are similar to those found in continental populations. These results indicate that the diversity of insular goat populations is modulated by multiple factors such as geographic distribution, population size, demographic history, trading and breed management. The online version of this article (10.1186/s12711-018-0425-7) contains supplementary material, which is available to authorized users.
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DOI：
10.1186/s12711-016-0229-6
发表时间：
2016-07-25
期刊：
Genetics, selection, evolution : GSE
影响因子：
--
作者：
Manunza A;Noce A;Serradilla JM;Goyache F;Martínez A;Capote J;Delgado JV;Jordana J;Muñoz E;Molina A;Landi V;Pons A;Balteanu V;Traoré A;Vidilla M;Sánchez-Rodríguez M;Sànchez A;Cardoso TF;Amills M
通讯作者：
Amills M
DOI：
10.1186/s12711-018-0422-x
发表时间：
2018-11-19
期刊：
Genetics, selection, evolution : GSE
影响因子：
--
作者：
Colli L;Milanesi M;Talenti A;Bertolini F;Chen M;Crisà A;Daly KG;Del Corvo M;Guldbrandtsen B;Lenstra JA;Rosen BD;Vajana E;Catillo G;Joost S;Nicolazzi EL;Rochat E;Rothschild MF;Servin B;Sonstegard TS;Steri R;Van Tassell CP;Ajmone-Marsan P;Crepaldi P;Stella A;AdaptMap Consortium
通讯作者：
AdaptMap Consortium
影响因子：
3.7
作者：
Di Gaetano C;Fiorito G;Ortu MF;Rosa F;Guarrera S;Pardini B;Cusi D;Frau F;Barlassina C;Troffa C;Argiolas G;Zaninello R;Fresu G;Glorioso N;Piazza A;Matullo G
通讯作者：
Matullo G
影响因子：
2.6
作者：
Lenstra, J. A.;Tigchelaar, J.;Oldenbroek, K.
通讯作者：
Oldenbroek, K.
影响因子：
2.4
作者：
Ferrando, A.;Manunza, A.;Amills, M.
通讯作者：
Amills, M.