Autonomic tone and C-reactive protein: a prospective population-based study.
Autonomic tone and C-reactive protein: a prospective population-based study.
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DOI：
10.1007/s10286-009-0019-0
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发表时间：
2009-12
影响因子：
5.8
通讯作者：
Masi, Christopher M.
中科院分区：
文献类型：
--
作者：
Singh, Puneet;Hawkley, Louise C.;McDade, Thomas W.;Cacioppo, John T.;Masi, Christopher M.
检查心脏自主神经张力和血清 CRP 之间的横断面和纵向关系，并研究这些指标之间的潜在因果关系。来自伊利诺伊州库克县的 188 名居家中年人和老年人（104 名女性，平均年龄 59 岁）组成的人口样本参与了这项前瞻性队列研究。高频心率变异性（HF）和射血前期（PEP）分别作为心脏副交感神经和交感神经张力的标志。心脏自主平衡（CAB）定义为 HF 和 PEP 标准化值之间的算术差。多元回归和自回归交叉滞后面板分析分别用于研究横截面和纵向关系。高敏酶联免疫法测定血清CRP。剔除3例CRP值提示急性炎症的病例后，平均CRP值为1.43mg/L（范围0.02-7.96mg/L，SD = 1.55）。在根据性别、年龄、种族/民族、教育、体重指数、吸烟、运动、收缩压和健康状况（包括糖尿病和高血压）进行调整的模型中，HF（B = -0.15，SE = 0.04，P < 0.01）和CAB（B = -0.14，SE = 0.04，P < 0.01）与自然对数（ln）CRP显着相关。在纵向分析中，任何一年中较高的 CRP 水平都预示着下一年心力衰竭的增加更大。横断面分析中 HF 与 CRP 之间的负相关关系与之前的研究一致，而纵向结果表明，由于循环 CRP 较高，心脏副交感张力可能会随着时间的推移而增加。
To examine the cross-sectional and longitudinal relationships between cardiac autonomic tone and serum CRP and to investigate potential causal links between these measures. A population-based sample of 188 home-dwelling, middle-aged and older adults (104 women, mean age 59 years) from Cook County, IL, participated in this prospective cohort study. High-frequency heart rate variability (HF) and pre-ejection period (PEP) served as markers of cardiac parasympathetic and sympathetic tone, respectively. Cardiac autonomic balance (CAB) was defined as the arithmetic difference between normalized values of HF and PEP. Multivariate regression and autoregressive cross-lagged panel analyses were used to investigate cross-sectional and longitudinal relationships, respectively. High-sensitivity enzyme immunoassay measured serum CRP. After removing three cases with CRP values suggesting acute inflammation, the mean CRP value was 1.43 mg/L (range 0.02–7.96 mg/L, SD = 1.55). In models that adjusted for gender, age, race/ethnicity, education, body mass index, smoking, exercise, systolic blood pressure and health conditions including diabetes and hypertension, HF (B = −0.15, SE = 0.04, P < 0.01) and CAB (B = −0.14, SE = 0.04, P < 0.01) were significantly associated with natural log (ln) CRP. In longitudinal analysis, higher CRP levels in any one year predicted greater increases in HF in the subsequent year. The inverse relationship between HF and CRP in cross-sectional analysis is consistent with previous studies, while the longitudinal results suggest that cardiac parasympathetic tone may increase over time as a result of higher circulating CRP.
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影响因子：
5.5
作者：
MCPHILLIPS, JB;PELLETTERA, KM;CRIQUI, MH
通讯作者：
CRIQUI, MH
DOI：
10.1111/j.1532-5415.2007.01564.x
发表时间：
2008-02-01
影响因子：
6.3
作者：
Stein, Phyllis K.;Barzilay, Joshua I.;Gottdiener, John S.
通讯作者：
Gottdiener, John S.
影响因子：
37.8
作者：
Pearson, TA;Mensah, GA;Vinicor, F
通讯作者：
Vinicor, F
影响因子：
3.8
作者：
Berntson, Gary G.;Norman, Greg J.;Cacioppo, John T.
通讯作者：
Cacioppo, John T.
影响因子：
3.3
作者：
McDade, Thomas W.;Hawkley, Louise C.;Cacioppo, John T.
通讯作者：
Cacioppo, John T.