Differences in aqueous concentrations of cytokines in macular edema secondary to branch and central retinal vein occlusion.
Differences in aqueous concentrations of cytokines in macular edema secondary to branch and central retinal vein occlusion.
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DOI：
10.1371/journal.pone.0068149
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Jiang Y
中科院分区：
文献类型：
--
作者：
Feng J;Zhao T;Zhang Y;Ma Y;Jiang Y
本研究探讨了因视网膜分支静脉阻塞 (BRVO) 或视网膜中央静脉阻塞导致黄斑水肿的眼睛中白细胞介素 6、8、1β（分别为 IL-6、IL-8、IL-1β）、血清淀粉样蛋白 A (SAA)、转化生长因子 (TGF)-β、碱性成纤维细胞生长因子 (bFGF) 和血管内皮生长因子 (VEGF) 的房水浓度差异（CRVO）。 CRVO 和 BRVO 患者房水中的 IL-6、IL-8、IL-1β、TGF-β、bFGF、SAA 和 VEGF 浓度显着高于对照患者房水中。 BRVO患者的bFGF浓度与内中央黄斑厚度（CMT）之间存在显着相关性（r = 0.688；P = 0.02）。缺血组SAA浓度与全CMT和外CMT之间均存在显着相关性（r 分别= 0.545和0.683；P 分别= 0.04和0.01）。在非缺血组中，IL-6水平与内部CMT显着相关（r = 0.560；P = 0.03）。 4周时玻璃体内注射贝伐单抗（IVB）后，CRVO患者的全CMT和外CMT均显着低于BRVO患者（P = 0.02和0.02）。血清淀粉样蛋白A作为参与急性和慢性炎症阶段的主要蛋白，IL-6和bFGF与RVO患者黄斑水肿程度显着相关。除 VEGF 外，其他炎症细胞因子和血管生成因子也可能与 RVO 相关。这一发现可能对 RVO 的医学治疗有影响。
This study investigates the differential aqueous concentrations of interleukin 6, 8, 1β (IL-6, IL-8, IL-1β, respectively), serum amyloid A (SAA), transforming growth factor (TGF)-β, basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF) in eyes with macular edema as a result of a branch retinal vein occlusion (BRVO) or central retinal vein occlusion (CRVO). Significantly higher concentrations of IL-6, IL-8, IL-1β, TGF-β, bFGF, SAA, and VEGF were found in the aqueous humor of CRVO and BRVO patients than in the aqueous humor of control patients. A significant correlation was observed between the concentration of bFGF and the inner central macular thickness (CMT) of BRVO patients (r = 0.688; P = 0.02). A significant correlation was observed between the concentration of SAA and both the full and outer CMT of the ischemic group (r = 0.545 and 0.683, respectively; P = 0.04 and 0.01, respectively). In the non-ischemic group, the level of IL-6 was significantly associated with inner CMT (r = 0.560; P = 0.03). The full and outer CMT was significantly reduced in CRVO patients when compared with BRVO patients (P = 0.02 and 0.02, respectively) after injection of intravitreal bevacizumab (IVB) at 4 weeks. Serum amyloid A as a major protein involved in the acute and chronic stages of inflammation, and IL-6 and bFGF were significantly associated with the extent of macular edema in patients with RVO. Besides VEGF, other inflammatory cytokines and angiogenesic factors may be associated with RVO. This finding may have implications for the medical treatment of RVO.
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影响因子：
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作者：
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