Antibody molecules discriminate between crystalline facets of a gallium arsenide semiconductor.
Antibody molecules discriminate between crystalline facets of a gallium arsenide semiconductor.
复制标题
抗体分子区分砷化镓半导体的晶面。
DOI：
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
U. Sivan
中科院分区：
文献类型：
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作者：
Arbel Artzy Schnirman;E. Zahavi;Hadas Yeger;Ronit Rosenfeld;I. Benhar;Y. Reiter;U. Sivan
生物分子与人造材料的无缝整合很可能依赖于分子识别和特异性结合。在下文中，我们展示了基于人类免疫系统的庞大库的组合抗体文库可以被利用来产生这样的结合剂。作为示范，我们分离出区别和选择性结合GaAs（111 A）面而不是GaAs（100）面的抗体片段。所述分离的抗体用于在包含（100）和（111 A）表面的混合物的结构中的（111 A）表面上唯一定位荧光染料。结构刚度的潜在重要性，小面识别建议相对于已发表的实验与短和较长的肽。
Seamless integration of biomolecules with manmade materials will most likely rely on molecular recognition and specific binding. In the following we show that combinatorial antibody libraries, based on the vast repertoire of the human immune system, can be harnessed to generate such binders. As a demonstration, we isolate antibody fragments that discriminate and bind selectively GaAs (111A) facets as opposed to GaAs (100). The isolated antibodies are utilized for exclusive localization of a fluorescent dye on (111A) surfaces in a structure comprising a mixture of (100) and (111A) surfaces. The potential importance of structure rigidity to facet recognition is suggested vis-a-vis published experiments with short and longer peptides.
DOI：
10.1073/pnas.89.18.8651
发表时间：
1992-09-15
影响因子：
11.1
作者：
BROWN, S
通讯作者：
BROWN, S
影响因子：
56.9
作者：
SMITH, GP
通讯作者：
SMITH, GP