Layer-specific anatomical, physiological and functional MRI of the retina.
Layer-specific anatomical, physiological and functional MRI of the retina.
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DOI:
10.1002/nbm.1311
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发表时间:
2008-11
影响因子:
2.9
通讯作者:
Shen, Qiang
中科院分区:
文献类型:
--
作者:
Duong, Timothy Q.;Pardue, Machelle T.;Thule, Peter M.;Olson, Darin E.;Cheng, Haiying;Nair, Govind;Li, Yingxia;Kim, Moon;Zhang, Xiaodong;Shen, Qiang
关键词:
Most retinal imaging has been performed using optical techniques. This paper reviews alternative retinal imaging methods based on magnetic resonance imaging (MRI) performed with spatial resolution sufficient to resolve multiple well-defined retinal layers. The development of these MRI technologies to study retinal anatomy, physiology (blood flow, blood volume, and oxygenation) and function, and their applications to study normal retinas, retinal degeneration and diabetic retinopathy in animal models are discussed. While the spatiotemporal resolution of MRI is poorer than optical imaging techniques, MRI is unhampered by media opacity and can thus image all retinal and pararetinal structures, and has the potential to provide multiple unique clinically relevant data in a single setting and could thus complement existing retinal imaging techniques. In turn, the highly structured retina with well-defined layers serves as an excellent model to advance emerging high-resolution anatomic, physiologic and functional MRI technologies.
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