Pilot Study of Metabolomics and Psychoneurological Symptoms in Women With Early Stage Breast Cancer.
Pilot Study of Metabolomics and Psychoneurological Symptoms in Women With Early Stage Breast Cancer.
复制标题
DOI：
10.1177/1099800417747411
复制
发表时间：
2018-03
影响因子：
2.5
通讯作者：
Jackson-Cook C
中科院分区：
文献类型：
--
作者：
Lyon DE;Starkweather A;Yao Y;Garrett T;Kelly DL;Menzies V;Dereziński P;Datta S;Kumar S;Jackson-Cook C
许多乳腺癌女性在化疗期间和化疗后会出现疼痛、疲劳和抑郁症状，统称为精神神经 (PN) 症状。越来越多的证据表明，与癌症及其治疗相关的炎症功能障碍通过几个相互关联的途径导致 PN 症状的发生和持续。然而，更准确地识别这些症状背后的生物学机制的一个主要限制因素是缺乏代表整体生物反应谱的生物学测量方法。代谢组学可以检查多种同时发生的代谢途径，并提供可能导致 PN 症状的生物机制的系统级视角。在这项初步研究中，我们使用液相色谱高分辨率质谱法对 19 名早期乳腺癌女性的存档样本中色氨酸途径的整体和靶向代谢组学进行了血清代谢组分析。我们使用配对 t 检验来比较代谢物浓度，并使用 Pearson 相关系数来检查化疗前后代谢物浓度和 PN 症状的伴随变化。化疗后疼痛、疲劳和抑郁程度加剧。与化疗前相比，化疗后的总体代谢物的特点是乙酰-L-丙氨酸和硫酸吲哚酚浓度较高，5-氧代-L-脯氨酸水平较低。靶向分析表明化疗后犬尿氨酸水平和犬尿氨酸/色氨酸比率显着升高。疼痛和疲劳症状与多种全局和几种目标代谢物有很强的相关性。结果表明，代谢组学可能有助于阐明早期乳腺癌女性 PN 症状（特别是疼痛和疲劳）的发展和严重程度相关的生物学机制。
Many women with breast cancer experience symptoms of pain, fatigue, and depression, collectively known as psychoneurologic (PN) symptoms, during and after chemotherapy treatment. Evidence that inflammatory dysfunction related to cancer and its treatments contributes to the development and persistence of PN symptoms through several interrelated pathways is accumulating. However, a major limiting factor in more precisely identifying the biological mechanisms underlying these symptoms is the lack of biological measures that represent a holistic spectrum of biological responses. Metabolomics allows for examination of multiple, co-occurring metabolic pathways and provides a systems-level perspective on biological mechanisms that may contribute to PN symptoms. In this pilot study, we performed serum metabolome analysis using liquid chromatography high-resolution mass spectrometry of global and targeted metabolomics from the tryptophan pathway from archived samples from 19 women with early-stage breast cancer. We used paired t tests to compare metabolite concentrations and Pearson’s correlation coefficients to examine concomitant changes in metabolite concentrations and PN symptoms before and after chemotherapy. Levels of pain, fatigue, and depression increased after chemotherapy. Compared with pre-chemotherapy, global metabolites post-chemotherapy were characterized by higher concentrations of acetyl-L-alanine and indoxyl sulfate and lower levels of 5-oxo-L-proline. Targeted analysis indicated significantly higher kynurenine levels and kynurenine/tryptophan ratios post-chemotherapy. Symptoms of pain and fatigue had strong associations with multiple global and several targeted metabolites. Results demonstrated that metabolomics may be useful for elucidating biological mechanisms associated with the development and severity of PN symptoms, specifically pain and fatigue, in women with early-stage breast cancer.
登录
查看更多内容
影响因子：
3.7
作者：
Jones, Salene M. W.;LaCroix, Andrea Z.;Danhauer, Suzanne C.
通讯作者：
Danhauer, Suzanne C.
影响因子：
--
作者：
Dantzer R
通讯作者：
Dantzer R
影响因子：
2.5
作者：
Lyon D;Elmore L;Aboalela N;Merrill-Schools J;McCain N;Starkweather A;Elswick RK Jr;Jackson-Cook C
通讯作者：
Jackson-Cook C
影响因子：
9.7
作者：
Blinder, Victoria;Eberle, Carolyn;Bradley, Cathy J.
通讯作者：
Bradley, Cathy J.
DOI：
10.1007/978-3-319-52479-5_9
发表时间：
2017-01-01
期刊：
PROTEOMIC METHODS IN NEUROPSYCHIATRIC RESEARCH
影响因子：
--
作者：
Guest, Paul C.;Rahmoune, Hassan
通讯作者：
Rahmoune, Hassan