Sensitive protein alignments at tree-of-life scale using DIAMOND.
Sensitive protein alignments at tree-of-life scale using DIAMOND.
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DOI:
10.1038/s41592-021-01101-x
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发表时间:
2021-04
期刊:
影响因子:
48
通讯作者:
Drost HG
中科院分区:
文献类型:
--
作者:
Buchfink B;Reuter K;Drost HG
We are at the beginning of a genomic revolution in which all known species are planned to be sequenced. Accessing such data for comparative analyses is crucial in this new age of data-driven biology. Here, we introduce an improved version of DIAMOND that greatly exceeds previous search performances and harnesses supercomputing to perform tree-of-life scale protein alignments in hours, while matching the sensitivity of the gold standard BLASTP. An updated version of DIAMOND uses improved algorithmic procedures and a customized high-performance computing framework to make seemingly prohibitive large-scale protein sequence alignments feasible.
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