Mol* Viewer: modern web app for 3D visualization and analysis of large biomolecular structures.
Mol* Viewer: modern web app for 3D visualization and analysis of large biomolecular structures.
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DOI：
10.1093/nar/gkab314
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发表时间：
2021-07-02
影响因子：
14.9
通讯作者：
Rose AS
中科院分区：
文献类型：
--
作者：
Sehnal D;Bittrich S;Deshpande M;Svobodová R;Berka K;Bazgier V;Velankar S;Burley SK;Koča J;Rose AS
大的生物分子结构每天都在使用已建立的技术（如晶体学和电子显微镜）进行实验测定。此外，新兴的综合或混合方法（I/HM）正在产生巨大的大分子机器和组件的结构模型，有时包含数十亿个非氢原子。对提供这些数据的可视化和分析工具的性能要求正在迅速提高。在开发在线、网络原生三维（3D）可视化工具方面取得的重大进展，以前是通过引入LiteMol套件和NGL Viewer完成的。此后，PDBe和RCSB PDB共同发起了Mol* 的开发，以联合收割机结合并建立LiteMol（由PDBe开发）和NGL（由RCSB PDB开发）的优势。网络原生Mol* Viewer可实现大分子坐标和实验数据的3D可视化和流式传输，并具有显示结构质量、功能或生物背景注释的功能。高性能图形和数据管理允许用户同时可视化多达数百个（叠加）蛋白质结构，流式分子动力学模拟轨迹，渲染细胞级模型或显示巨大的I/HM结构。它是PDBe和RCSB PDB使用的主要3D结构查看器。它可以很容易地集成到第三方服务中。Mol* Viewer是开源的，可在https://molstar.org/上免费获得。Mol* Viewer可可视化和操作的大量实体和系统概览。
Large biomolecular structures are being determined experimentally on a daily basis using established techniques such as crystallography and electron microscopy. In addition, emerging integrative or hybrid methods (I/HM) are producing structural models of huge macromolecular machines and assemblies, sometimes containing 100s of millions of non-hydrogen atoms. The performance requirements for visualization and analysis tools delivering these data are increasing rapidly. Significant progress in developing online, web-native three-dimensional (3D) visualization tools was previously accomplished with the introduction of the LiteMol suite and NGL Viewers. Thereafter, Mol* development was jointly initiated by PDBe and RCSB PDB to combine and build on the strengths of LiteMol (developed by PDBe) and NGL (developed by RCSB PDB). The web-native Mol* Viewer enables 3D visualization and streaming of macromolecular coordinate and experimental data, together with capabilities for displaying structure quality, functional, or biological context annotations. High-performance graphics and data management allows users to simultaneously visualise up to hundreds of (superimposed) protein structures, stream molecular dynamics simulation trajectories, render cell-level models, or display huge I/HM structures. It is the primary 3D structure viewer used by PDBe and RCSB PDB. It can be easily integrated into third-party services. Mol* Viewer is open source and freely available at https://molstar.org/. Overview of the large array of entities and systems that can be visualized and be manipulated with by the Mol* Viewer.
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影响因子：
14.9
作者：
Mistry J;Chuguransky S;Williams L;Qureshi M;Salazar GA;Sonnhammer ELL;Tosatto SCE;Paladin L;Raj S;Richardson LJ;Finn RD;Bateman A
通讯作者：
Bateman A
影响因子：
4.3
作者：
Sehnal D;Bittrich S;Velankar S;Koča J;Svobodová R;Burley SK;Rose AS
通讯作者：
Rose AS
影响因子：
14.9
作者：
wwPDB consortium
通讯作者：
wwPDB consortium
影响因子：
14.9
作者：
Mir S;Alhroub Y;Anyango S;Armstrong DR;Berrisford JM;Clark AR;Conroy MJ;Dana JM;Deshpande M;Gupta D;Gutmanas A;Haslam P;Mak L;Mukhopadhyay A;Nadzirin N;Paysan-Lafosse T;Sehnal D;Sen S;Smart OS;Varadi M;Kleywegt GJ;Velankar S
通讯作者：
Velankar S
影响因子：
16
作者：
Beliu, Gerti;Altrichter, Steffen;Langenhan, Tobias
通讯作者：
Langenhan, Tobias