Mechanisms of innate lymphoid cell and natural killer T cell activation during mucosal inflammation.
Mechanisms of innate lymphoid cell and natural killer T cell activation during mucosal inflammation.
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DOI：
10.1155/2014/546596
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发表时间：
2014
影响因子：
4.1
通讯作者：
Mattner J
中科院分区：
文献类型：
--
作者：
Nau D;Altmayer N;Mattner J
气道和胃肠道中的粘液表面对于宿主与其环境的相互作用至关重要。由于它们在粘膜组织部位的丰富性和它们强大的免疫调节能力，先天淋巴样细胞（ILC）和自然杀伤T（NKT）细胞在维持粘膜耐受中的作用最近已成为关注的焦点。虽然NKT细胞以及ILC利用不同的转录因子用于它们的发育和谱系多样化，但两种细胞群体可以进一步分为三个极化亚群，反映了适应性免疫系统中Th1、Th2和Th17细胞的区别。虽然通过细胞因子的旁观者活化介导ILC和NKT细胞应答的诱导，但NKT细胞也通过其典型T细胞受体（TCR）被抗原呈递细胞（APC）上的非典型MHC I样分子CD 1d呈递的（糖）脂质抗原（同源识别）接合而被活化。由于这两种先天淋巴细胞群体由于大量不同细胞因子的爆炸性释放而影响炎症反应，因此它们可能是临床干预的有趣靶点。因此，我们将提供一个前景的途径，可能是有趣的，在这种情况下进行评估。
Mucosal surfaces in the airways and the gastrointestinal tract are critical for the interactions of the host with its environment. Due to their abundance at mucosal tissue sites and their powerful immunomodulatory capacities, the role of innate lymphoid cells (ILCs) and natural killer T (NKT) cells in the maintenance of mucosal tolerance has recently moved into the focus of attention. While NKT cells as well as ILCs utilize distinct transcription factors for their development and lineage diversification, both cell populations can be further divided into three polarized subpopulations reflecting the distinction into Th1, Th2, and Th17 cells in the adaptive immune system. While bystander activation through cytokines mediates the induction of ILC and NKT cell responses, NKT cells become activated also through the engagement of their canonical T cell receptors (TCRs) by (glyco)lipid antigens (cognate recognition) presented by the atypical MHC I like molecule CD1d on antigen presenting cells (APCs). As both innate lymphocyte populations influence inflammatory responses due to the explosive release of copious amounts of different cytokines, they might represent interesting targets for clinical intervention. Thus, we will provide an outlook on pathways that might be interesting to evaluate in this context.
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影响因子：
82.9
作者：
通讯作者：
--
影响因子：
30.5
作者：
Bernink, Jochem H.;Peters, Charlotte P.;Spits, Hergen
通讯作者：
Spits, Hergen
影响因子：
64.8
作者：
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--
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DOI：
10.1084/jem.20111594
发表时间：
2012-04-09
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Cherrier M;Sawa S;Eberl G
通讯作者：
Eberl G
影响因子：
20.3
作者：
Ahn, Yong-Oon;Blazar, Bruce R.;Verneris, Michael R.
通讯作者：
Verneris, Michael R.