Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells.
Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells.
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Notch，ID2和RORγT顺序策划了淋巴组织诱导剂细胞的胎儿发育。
DOI：
10.1084/jem.20111594
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发表时间：
2012-04-09
期刊：
影响因子：
--
通讯作者：
Eberl G
中科院分区：
文献类型：
--
作者：
Cherrier M;Sawa S;Eberl G
Notch信号传导是产生α4β7+RORγt−胎儿祖细胞所必需的，但必须关闭以允许RORγt表达和LTi细胞成熟。类淋巴结组织发育是在胚胎发生期间通过淋巴组织诱导物（LTi）细胞从胎肝迁移到外周而启动的，在外周它们诱导淋巴结和派尔集合淋巴结的形成。在胎肝中，表达整联蛋白α4β7的常见淋巴祖细胞（CLP）亚群产生LTi细胞，这一过程严格依赖于转录抑制因子Id 2和核激素受体视黄酸相关孤儿受体γ t（RORγt）的表达。在这项研究中，我们发现Id 2和RORγt在LTi细胞发育过程中依次上调，这与两波分化相匹配，对Notch信号的要求相反。Id 2和Notch的表达都是产生α4β7+ RORγt-胎儿祖细胞所必需的，但Notch随后阻止了RORγt+期的进展和LTi细胞的最终成熟。因此，Notch是参与LTi发育途径的必要开关，但随后需要关闭以避免转向T细胞命运。
Notch signaling is required for the generation of α4β7+RORγt− fetal progenitors, but must then be turned off to allow RORγt expression and LTi cell maturation. Lymphoid tissue development is initiated during embryogenesis by the migration of lymphoid tissue inducer (LTi) cells from the fetal liver to the periphery, where they induce the formation of lymph nodes and Peyer’s patches. In the fetal liver, a subset of common lymphoid progenitors (CLPs) that expresses the integrin α4β7 gives rise to LTi cells, a process strictly dependent on the expression of the transcriptional repressor Id2 and the nuclear hormone receptor retinoic acid–related orphan receptor γ t (RORγt). In this study, we show that Id2 and RORγt are sequentially up-regulated during LTi cell development, matching two waves of differentiation with opposite requirements for Notch signaling. Both the expression of Id2 and Notch are required for the generation of α4β7+ RORγt− fetal progenitors, but Notch subsequently blocks progression to the RORγt+ stage and final maturation of LTi cells. Notch is therefore a necessary switch to engage the LTi developmental pathway, but needs to be turned off later to avoid diversion to the T cell fate.
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影响因子：
64.5
作者：
Ivanov, Ivaylo I.;McKenzie, Brent S.;Littman, Dan R.
通讯作者：
Littman, Dan R.
影响因子：
30.5
作者：
通讯作者：
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影响因子：
64.8
作者：
Cella, Marina;Fuchs, Anja;Vermi, William;Facchetti, Fabio;Otero, Karel;Lennerz, Jochen K. M.;Doherty, Jason M.;Mills, Jason C.;Colonna, Marco
通讯作者：
Colonna, Marco
DOI：
10.1084/jem.143.4.772
发表时间：
1976-04-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Kiessling R;Petranyi G;Kärre K;Jondal M;Tracey D;Wigzell H
通讯作者：
Wigzell H
影响因子：
32.4
作者：
Feyerabend, Thorsten B.;Terszowski, Grzegorz;Rodewald, Hans-Reimer
通讯作者：
Rodewald, Hans-Reimer