5HT(2A) and 5HT(2B) receptors contribute to serotonin-induced vascular dysfunction in diabetes.
5HT(2A) and 5HT(2B) receptors contribute to serotonin-induced vascular dysfunction in diabetes.
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DOI：
10.1155/2012/398406
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发表时间：
2012
影响因子：
--
通讯作者：
Lamping KG
中科院分区：
文献类型：
--
作者：
Nelson PM;Harrod JS;Lamping KG
虽然5 HT 2A受体介导正常动脉对5-羟色胺（5-HT）的收缩，但在某些心血管疾病中，其他受体亚型有助于5-羟色胺收缩的显著增加。我们假设糖尿病患者对5 HT的动脉收缩增强是由多种5 HT受体亚型的贡献增加介导的。我们比较了非糖尿病小鼠（ND）与2型糖尿病小鼠（DB，BKS. Cg-Dock 7 m+/+Leprdb/J）对选择性5 HT受体激动剂的反应和主动脉中5 HT受体亚型（5 HT 1B，5 HT 2A和5 HT 2B）的表达。5 HT、5 HT 2A（TCB 2和BRL 54443）和5 HT 2B（去甲芬氟拉明和BW 723 C86）受体激动剂引起ND动脉的浓度依赖性收缩，而DB动脉的收缩明显增加。ND和DB动脉均不对5 HT 1B受体激动剂收缩。5-HT 2A受体拮抗剂MDL 11939和5-HT 2B受体拮抗剂LY 272015对DB-5-HT动脉收缩的抑制作用大于ND。5 HT 1B、5 HT 2A和5 HT 2B受体亚型在ND和DB中的表达相似。在ND和DB中，rho激酶的抑制降低了对5 HT和5 HT 2A和5 HT 2B受体激动剂的收缩。我们的结论是，与其他心血管疾病相比，从糖尿病患者到5 HT的动脉收缩增强不是由于多种5 HT受体亚型表达的变化。
Although 5HT2A receptors mediate contractions of normal arteries to serotonin (5HT), in some cardiovascular diseases, other receptor subtypes contribute to the marked increase in serotonin contractions. We hypothesized that enhanced contractions of arteries from diabetics to 5HT are mediated by an increased contribution from multiple 5HT receptor subtypes. We compared responses to selective 5HT receptor agonists and expression of 5HT receptor isoforms (5HT1B, 5HT2A, and 5HT2B) in aorta from nondiabetic (ND) compared to type 2 diabetic mice (DB, BKS.Cg-Dock7 m+/+Leprdb/J). 5HT, 5HT2A (TCB2 and BRL54443), and 5HT2B (norfenfluramine and BW723C86) receptor agonists produced concentration-dependent contractions of ND arteries that were markedly increased in DB arteries. Neither ND nor DB arteries contracted to a 5HT1B receptor agonist. MDL11939, a 5HT2A receptor antagonist, and LY272015, a 5HT2B receptor antagonist, reduced contractions of arteries from DB to 5HT more than ND. Expression of 5HT1B, 5HT2A, and 5HT2B receptor subtypes was similar in ND and DB. Inhibition of rho kinase decreased contractions to 5HT and 5HT2A and 5HT2B receptor agonists in ND and DB. We conclude that in contrast to other cardiovascular diseases, enhanced contraction of arteries from diabetics to 5HT is not due to a change in expression of multiple 5HT receptor subtypes.
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影响因子：
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作者：
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