Neural Indicators Of Food Cue Reactivity, Regulation, And Valuation And Their Associations With Body Composition And Daily Eating Behavior.
Neural Indicators Of Food Cue Reactivity, Regulation, And Valuation And Their Associations With Body Composition And Daily Eating Behavior.
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DOI：
10.1093/scan/nsaa155
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发表时间：
2020-11-20
影响因子：
4.2
通讯作者：
Lopez, Richard B.
中科院分区：
文献类型：
--
作者：
Cosme, Danielle;Lopez, Richard B.
暴露于食物线索激活大脑的奖励系统，破坏调节进食冲动的努力。在外显调节过程中，外侧前额叶皮层激活并调节奖赏区的活动，减少对食物的渴望。然而，在何种程度上的人与人之间的差异与奖励处理，主观评价和调节的区域招募食物提示确定性缺乏的指示，以调节预测身体成分和日常饮食行为是不清楚的。在这项预先注册的研究中，我们汇集了来自五个功能性磁共振成像（fMRI）样本（N = 262）的数据，以检查与奖励，评价和调节相关的区域，以及全脑模式表达索引这些过程，是否在食物提示暴露期间招募，并与身体成分和现实世界的饮食行为相关。一个先验的分析路径的回归模型表明，单变量和多变量的奖励和评价措施与个体差异的身体质量指数和制定日常的食物渴望。规范曲线分析进一步揭示了反应性、调节和评价的单变量和多变量神经指标与所有结果之间的可靠关联。这些研究结果突出了这些方法的实用性，以阐明大脑行为协会，并表明，多个过程中涉及近端和远端标记的饮食行为。
Exposure to food cues activates the brain’s reward system and undermines efforts to regulate impulses to eat. During explicit regulation, lateral prefrontal cortex activates and modulates the activity in reward regions and decreases food cravings. However, the extent to which between-person differences in the recruitment of regions associated with reward processing, subjective valuation and regulation during food cue exposure—absent instructions to regulate—predict body composition and daily eating behaviors is unclear. In this preregistered study, we pooled data from five functional magnetic resonance imaging (fMRI) samples (N = 262) to examine whether regions associated with reward, valuation and regulation, as well as whole-brain pattern expression indexing these processes, were recruited during food cue exposure and associated with body composition and real-world eating behavior. Regression models for a single a priori analytic path indicated that univariate and multivariate measures of reward and valuation were associated with individual differences in body mass index and the enactment of daily food cravings. Specification curve analyses further revealed reliable associations between univariate and multivariate neural indicators of reactivity, regulation and valuation and all outcomes. These findings highlight the utility of these methods to elucidate brain–behavior associations and suggest that multiple processes are implicated in proximal and distal markers of eating behavior.
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影响因子：
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通讯作者：
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