Decreased expression of granulocyte-macrophage colony-stimulating factor is associated with adverse clinical outcome in patients with gastric cancer undergoing gastrectomy.
Decreased expression of granulocyte-macrophage colony-stimulating factor is associated with adverse clinical outcome in patients with gastric cancer undergoing gastrectomy.
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粒细胞巨噬细胞集落刺激因子表达降低与接受胃切除术的胃癌患者不良临床结果相关
DOI：
10.3892/ol.2017.6738
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发表时间：
2017-10
期刊：
影响因子：
2.9
通讯作者：
Sun Y
中科院分区：
文献类型：
--
作者：
Liu H;Lin C;Shen Z;Zhang H;He H;Li H;Qin J;Qin X;Xu J;Sun Y
先前的研究已经揭示了肿瘤相关巨噬细胞（TAM）在胃癌中的临床意义，而协调TAM极化的细胞因子在胃癌中的作用仍然难以捉摸。本研究旨在探讨粒细胞-巨噬细胞集落刺激因子（GM-CSF）表达对胃癌患者预后的价值。采用免疫组化染色方法对408例回顾性病例的肿瘤内GM-CSF表达进行了研究。采用Kaplan-Meier分析和考克斯回归模型评价GM-CSF表达对预后的影响。生成预测列线图以预测患者的总生存率和无病生存率。发现肿瘤内GM-CSF表达降低，表明胃癌患者的临床结局较差，尤其是在晚期。根据肿瘤-淋巴结-转移（TNM）分期系统，肿瘤内GM-CSF表达可能为胃癌患者的预后提供额外的风险分层。考克斯多变量分析表明GM-CSF表达是影响总生存期和无病生存期的独立预后因素。所生成的列线图在预测胃癌患者的3年和5年临床结局方面表现良好。总之，GM-CSF是一个潜在的独立的胃癌患者的预后指标，它可以与TNM分期系统相结合，以提高临床结果的预测准确性，特别是在晚期肿瘤。
Previous studies have revealed the clinical significance of tumor-associated macrophages (TAMs) in gastric cancer, whereas the role of the cytokines that orchestrate TAM polarization in gastric cancer remains elusive. The present study aimed to evaluate the prognostic value of granulocyte-macrophage colony-stimulating factor (GM-CSF) expression in patients with gastric cancer. Intratumoral GM-CSF expression was investigated by immunohistochemical staining in 408 retrospectively enrolled patients. Kaplan-Meier analysis and Cox regression models were used to evaluate the prognostic value of GM-CSF expression. Predictive nomograms were generated to predict the overall survival and disease-free survival rates of the patients. Decreased intratumoral GM-CSF expression was identified, and indicated a poorer clinical outcome for patients with gastric cancer, particularly in advanced stages. Intratumoral GM-CSF expression may provide an additional risk stratification for the prognosis of patients with gastric cancer based on the Tumor-Node-Metastasis (TNM) staging system. Cox multivariate analysis identified GM-CSF expression as an independent prognostic factor for overall survival and disease-free survival time. The generated nomograms performed well in predicting the 3-and 5-year clinical outcome of patients with gastric cancer. In conclusion, GM-CSF is a potential independent prognostic indicator for patients with gastric cancer, which may be integrated with TNM staging systems to improve the predictive accuracy for clinical outcome, particularly in advanced tumors.
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DOI：
10.1038/nri2528
发表时间：
2009-04
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1111/apm.1965.64.1.31
发表时间：
1965-01-01
期刊：
ACTA PATHOLOGICA ET MICROBIOLOGICA SCANDINAVICA
影响因子：
--
作者：
LAUREN, P
通讯作者：
LAUREN, P
肿瘤相关巨噬细胞促进胃癌的血管生成和淋巴管生成。
影响因子：
2.5
作者：
Wu, Hui;Xu, Jian-Bo;Cai, Shi-Rong
通讯作者：
Cai, Shi-Rong
影响因子：
32.4
作者：
Noy, Roy;Pollard, Jeffrey W.
通讯作者：
Pollard, Jeffrey W.
肿瘤源性 GM-CSF 通过刺激上皮释放 VEGF 促进炎症性结肠癌发生
影响因子：
11.2
作者：
Wang, Yi;Han, Gencheng;Chen, Guojiang
通讯作者：
Chen, Guojiang