Dietary magnesium intake is inversely associated with serum C-reactive protein levels: meta-analysis and systematic review.
Dietary magnesium intake is inversely associated with serum C-reactive protein levels: meta-analysis and systematic review.
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DOI：
10.1038/ejcn.2014.7
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发表时间：
2014-04
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
定量总结一般人群膳食镁（Mg）摄入量与血清C反应蛋白（CRP）水平的关系。在PubMed和EMBASE中审查了截至2013年2月的观察性和实验性研究。通过Google或手动搜索相关参考文献列表检索了其他信息。主要结局是CRP的校正几何平均值或血清CRP≥3 mg/L的比值比（OR）。荟萃回归用于确定膳食镁摄入量与CRP水平校正几何平均值的线性关系。使用固定效应模型来汇总感兴趣的OR，比较膳食镁摄入量最低组与最高组的OR。对来自7项横断面研究（包括32，918名参与者）的数据集进行了定量评估。从4项横断面研究中观察到镁摄入量与血清CRP水平之间存在加权负相关[β系数：−0.0028; 95%CI，−0.0043至−0.0013;趋势P =0.001]。CRP≥3 mg/L的合并OR（95%CI）为1.49（1.18 - 1.89），比较了3项研究中镁摄入量最低组与最高组的数据。五项干预研究的定性评估也显示镁摄入对血清CRP水平的潜在有益影响。这项荟萃分析和系统评价表明，膳食镁摄入量与血清CRP水平显着负相关。镁摄入量对慢性疾病的潜在有益影响至少可以部分通过抑制炎症来解释。
To quantitatively summarize the association of dietary magnesium (Mg) intake with serum C-reactive protein (CRP) levels in the general population. Observational and experimental studies through February 2013 were reviewed in PubMed and EMBASE. Additional information was retrieved through Google or hand search of related reference lists. The main outcome is either adjusted geometric mean of CRP or odds ratio (OR) of having serum CRP≥3 mg/L. Meta-regression was used to determine the linear association of dietary Mg intake and adjusted geometric means of CRP levels. A fixed-effects model was used to pool ORs of interest, comparing those in the lowest with those in the highest group of dietary Mg intake. A dataset derived from seven cross-sectional studies including 32,918 participants was quantitatively assessed. A weighted inverse association between Mg intake and serum CRP levels was observed[β coefficient: −0.0028; 95% CI, −0.0043 to −0.0013; P for trend=0.001] from four cross-sectional studies. The pooled OR (95%CI) of having CRP≥3 mg/L was 1.49(1.18 to 1.89) comparing the lowest to the highest group of Mg intake from three studies with data available. Qualitative assessment among five intervention studies also showed a potential beneficial effect of Mg intake on serum CRP levels. This meta-analysis and systematic review indicate that dietary Mg intake is significantly and inversely associated with serum CRP levels. The potential beneficial effect of Mg intake on chronic diseases may be, at least in part, explained by inhibiting inflammation.
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影响因子：
4.5
作者：
King, Dana E.;Mainous, Arch G., III;Rehman, Shakeib
通讯作者：
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影响因子：
2.9
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6.1
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Rayssiguier, Y
影响因子：
3.2
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通讯作者：
Guerrero-Romero, Fernando
影响因子：
2
作者：
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通讯作者：
Thompson, SG