Bacterial second messenger 3',5'-cyclic diguanylate attracts Caenorhabditis elegans and suppresses its immunity.
Bacterial second messenger 3',5'-cyclic diguanylate attracts Caenorhabditis elegans and suppresses its immunity.
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细菌第二信使3'，5'-循环二甘氨酸盐吸引秀丽隐杆线虫，并抑制其免疫力。
DOI：
10.1038/s42003-020-01436-9
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发表时间：
2020-11-20
影响因子：
5.9
通讯作者：
Cao M
中科院分区：
文献类型：
--
作者：
Angeloni J;Dong Y;Wang Z;Cao M
环状二核苷酸是细菌中重要的次级信号分子，调节广泛的过程。在这项研究中，我们发现秀丽隐杆线虫可以检测到并吸引到霍乱弧菌产生的多种信号分子，特别是3′，5 ′-环二鸟苷酸（c-di-GMP），即使这种细菌以很高的速度杀死宿主。C-di-GMP通过C. elegans嗅觉AWC神经元，然后引发一系列信号转导途径，导致两个关键的应激反应转录因子SKN-1和HSF-1的活性降低，并削弱先天免疫。总之，我们的研究阐明了c-di-GMP在王国间通信中的作用。梭线虫，细菌c-di-GMP可以作为一个线索，他们可以用来检测食物。另一方面，预先暴露于低浓度的c-di-GMP可能会损害他们的免疫反应，这可能会促进细菌入侵和存活。Joseph Angeloni等人表明秀丽隐杆线虫可以检测到并被霍乱弧菌产生的多种信号分子所吸引，特别是3′，5 ′-环二鸟苷酸（c-di-GMP），即使这种细菌以很高的速度杀死宿主。这项研究揭示了细菌c-di-GMP如何作为C.它们可以用来检测食物，或者削弱它们的免疫反应，这可能有助于细菌入侵和生存。
Cyclic di-nucleotides are important secondary signaling molecules in bacteria that regulate a wide range of processes. In this study, we found that Caenorhabditis elegans can detect and are attracted to multiple signal molecules produced by Vibrio cholerae, specifically the 3′,5′-cyclic diguanylate (c-di-GMP), even though this bacterium kills the host at a high rate. C-di-GMP is sensed through C. elegans olfactory AWC neurons, which then evokes a series of signal transduction pathways that lead to reduced activity of two key stress response transcription factors, SKN-1 and HSF-1, and weakened innate immunity. Taken together, our study elucidates the role of c-di-GMP in interkingdom communication. For C. elegans, bacterial c-di-GMP may serve as a cue that they can use to detect food. On the other hand, preexposure to low concentrations of c-di-GMP may impair their immune response, which could facilitate bacterial invasion and survival. Joseph Angeloni et al. show that Caenorhabditis elegans can detect and are attracted to multiple signal molecules produced by the bacterium Vibrio cholerae, specifically the 3′,5′-cyclic diguanylate (c-di-GMP), even though this bacterium kills the host at a high rate. This study reveals how bacterial c-di-GMP may serve as a cue for C. elegans that they can use to detect food or alternatively, impair their immune response, which could facilitate bacterial invasion and survival.
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影响因子：
56.9
作者：
Garsin, DA;Villanueva, JM;Ausubel, FM
通讯作者：
Ausubel, FM
影响因子：
3.2
作者：
Hull, Travis D.;Ryu, Min-Hyung;Bennett, Jennifer A.
通讯作者：
Bennett, Jennifer A.
DOI：
10.1073/pnas.1419264112
发表时间：
2015-04-28
影响因子：
11.1
作者：
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通讯作者：
Breaker, Ronald R.
影响因子：
3.6
作者：
Fagerlund, Annette;Smith, Veronika;Okstad, Ole Andreas
通讯作者：
Okstad, Ole Andreas
影响因子：
7.8
作者：
Oliveira RP;Porter Abate J;Dilks K;Landis J;Ashraf J;Murphy CT;Blackwell TK
通讯作者：
Blackwell TK