A Prospective Study of Taxane-Induced Neuropathy with Breast Cancer: Proper Assessment Tool for Taxane-Induced Neuropathy.
A Prospective Study of Taxane-Induced Neuropathy with Breast Cancer: Proper Assessment Tool for Taxane-Induced Neuropathy.
复制标题
DOI：
10.1055/s-0041-1731100
复制
发表时间：
2021-04
影响因子：
0.5
通讯作者：
Kim JR
中科院分区：
文献类型：
--
作者：
Sohn EH;Lee JS;Jung MS;Kim JR
背景 许多化疗药物，尤其是紫杉烷类药物，可诱发周围神经病变。 目的 评估乳腺癌患者紫杉烷诱发神经病变 (TIN) 的临床特征，并确定适当的 TIN 评估工具。 背景和设计 单中心、观察性、前瞻性研究。 方法和材料 前瞻性招募了 43 名接受紫杉烷类治疗的乳腺癌患者。在基线和入组后 3 个月进行了简化版的总神经病变评分 (TNSr)。如果基线与 3 个月 TNSr 之间的差异大于 1，则诊断为 TIN。对于 TIN 患者，入组后 3 个月还对欧洲癌症研究和治疗组织生活质量问卷 — 化疗引起的周围神经病变（20 项量表 (EORTC-CIPN20)）进行评估。结果 43 名患者中有 37 名 (86.0%) 被诊断为 TIN。 感觉症状(64.9%) 是最常见的异常，其次是自主神经症状 (54.1%)。TNSr 感觉症状评分与 EORTC-CIPN20 呈正相关。与化疗前相比，所有测试神经的神经传导速度和振幅均降低；然而，只有 3 名患者 (8.1%) 的腓肠感觉神经动作电位振幅超出正常范围。结论 TIN 主要是感觉神经传导研究正常，这是小纤维神经病的主要特征，应考虑将基于临床医生的量表和患者报告的问卷以及针对小神经纤维的专门测试组成的组合量表作为评估 TIN 的适当评估工具。
Background Many chemotherapeutic agents, especially taxanes, can induce peripheral neuropathy. Aim To evaluate the clinical characteristics of taxane-induced neuropathy (TIN) and determine the proper assessment tool for TIN in patients with breast cancer. Setting and Design Single-center, observational, prospective study. Methods and Material Forty-three patients with breast cancer treated with taxanes were prospectively enrolled. The reduced version of the Total Neuropathy Score (TNSr) was performed at baseline and 3 months after enrollment. TIN was diagnosed if the difference between the baseline and 3-month TNSr was greater than 1. In patients with TIN, the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire— Chemotherapy-Induced Peripheral Neuropathy (20-item scale (EORTC-CIPN20) was also assessed 3 months after enrollment. Results Thirty-seven out of 43 (86.0%) patients were diagnosed with TIN. Sensory symptoms (64.9%) were the most frequent abnormality, followed by autonomic symptoms (54.1%). No patients reported motor symptoms or motor weakness. The TNSr sensory symptom score positively correlated with that of the EORTC-CIPN20. Nerve conduction studies showed reduced nerve conduction velocities and amplitudes after taxane treatment compared to those before chemotherapy in all tested nerves; however, only three (8.1%) patients had sural sensory nerve action potential amplitude outside normal limits. Conclusions TIN was predominantly sensory with normal nerve conduction studies which is the main feature of small fiber neuropathy. A combination scale comprising of a clinician-based scale and a patient-reported questionnaire and specialized tests for small nerve fibers should be considered as proper assessment tools to evaluate TIN.
登录
查看更多内容
影响因子：
11.2
作者：
Staff NP;Grisold A;Grisold W;Windebank AJ
通讯作者：
Windebank AJ
影响因子：
3.8
作者：
Monfort, Scott M.;Pan, Xueliang;Lustberg, Maryam B.
通讯作者：
Lustberg, Maryam B.
影响因子：
3.8
作者：
Molassiotis, Alex;Cheng, Hui Lin;Sundar, Raghav
通讯作者：
Sundar, Raghav
影响因子：
3.8
作者：
Cavaletti, G;Jann, S;Giussani, G
通讯作者：
Giussani, G
影响因子：
3.5
作者：
Smith, Ellen M. Lavoie;Barton, Debra L.;Qin, Rui;Steen, Preston D.;Aaronson, Neil K.;Loprinzi, Charles L.
通讯作者：
Loprinzi, Charles L.