Repetition suppression and plasticity in the human brain.
Repetition suppression and plasticity in the human brain.
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DOI：
10.1016/j.neuroimage.2009.06.034
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发表时间：
2009-10-15
期刊：
影响因子：
5.7
通讯作者：
Friston, Karl J.
中科院分区：
文献类型：
--
作者：
Garrido, Marta I.;Kilner, James M.;Kiebel, Stefan J.;Stephan, Klaas E.;Baldeweg, Torsten;Friston, Karl J.
神经元对重复事件反应的抑制是神经科学中普遍存在的现象。然而，基本的机制仍然在很大程度上未被探索。本研究的目的是研究由重复刺激引起的连接性的经验依赖性变化的时间演变。我们记录了事件相关电位（ERP）的频率变化的重复音。贝叶斯反演的动态因果模型（DCM）的ERP揭示了系统的重复依赖的变化，内在和外在的连接，在一个分层的皮层网络。重要的是，这些变化发生得非常快，在刺激间的间隔，涉及短期突触可塑性。此外，内在的（内源）连接表现出双相的变化，比外在的（源之间）连接，随着重复单调下降的变化快得多。这项研究表明，听觉知觉学习与人脑中的重复依赖可塑性有关。值得注意的是，使用EEG可以如此可靠和无创地量化内在和外在连接的明显变化。
The suppression of neuronal responses to a repeated event is a ubiquitous phenomenon in neuroscience. However, the underlying mechanisms remain largely unexplored. The aim of this study was to examine the temporal evolution of experience-dependent changes in connectivity induced by repeated stimuli. We recorded event-related potentials (ERPs) during frequency changes of a repeating tone. Bayesian inversion of dynamic causal models (DCM) of ERPs revealed systematic repetition-dependent changes in both intrinsic and extrinsic connections, within a hierarchical cortical network. Critically, these changes occurred very quickly, over inter-stimulus intervals that implicate short-term synaptic plasticity. Furthermore, intrinsic (within-source) connections showed biphasic changes that were much faster than changes in extrinsic (between-source) connections, which decreased monotonically with repetition. This study shows that auditory perceptual learning is associated with repetition-dependent plasticity in the human brain. It is remarkable that distinct changes in intrinsic and extrinsic connections could be quantified so reliably and non-invasively using EEG.
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影响因子：
5.7
作者：
Doeller, CF;Opitz, B;Schröger, E
通讯作者：
Schröger, E
DOI：
10.1098/rstb.2005.1622
发表时间：
2005-04-29
影响因子：
6.3
作者：
Friston, KJ
通讯作者：
Friston, KJ
DOI：
10.1037/0278-7393.19.4.909
发表时间：
1993-07-01
影响因子：
2.6
作者：
COWAN, N;WINKLER, I;NAATANEN, R
通讯作者：
NAATANEN, R
影响因子：
3.7
作者：
Felleman, Daniel J.;Van Essen, David C.
通讯作者：
Van Essen, David C.
DOI：
10.1016/j.clinph.2008.11.029
发表时间：
2009-03
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Garrido MI;Kilner JM;Stephan KE;Friston KJ
通讯作者：
Friston KJ