Association between usual sodium and potassium intake and blood pressure and hypertension among U.S. adults: NHANES 2005-2010.
Association between usual sodium and potassium intake and blood pressure and hypertension among U.S. adults: NHANES 2005-2010.
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DOI：
10.1371/journal.pone.0075289
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Yang Q
中科院分区：
文献类型：
--
作者：
Zhang Z;Cogswell ME;Gillespie C;Fang J;Loustalot F;Dai S;Carriquiry AL;Kuklina EV;Hong Y;Merritt R;Yang Q
研究表明，高钠和低钾的摄入会增加血压，这表明钠与钾的比例可能会提供信息。然而，有限的研究调查了钠钾比与血压和高血压的关系。我们分析了2005-2010年全国健康与营养调查中年龄≥20岁的10,563名参与者的数据，这些参与者既没有服用抗高血压药物，也没有低钠饮食。我们使用测量误差模型来估计日常摄入量，使用多变量线性回归来评估其与血压的关系，使用逻辑回归来评估其与高血压的关系。钠、钾和钠钾比的平均日常摄入量分别为3569 mg/d、2745 mg/d和1.41 mg/d。所有三项测量均与收缩压显著相关，钠或钾摄入量每增加1,000 mg/d分别增加1.04 mmHg （95% CI, 0.27-1.82）和降低1.24 mmHg (95% CI, 0.31-2.70)，钠钾比每增加0.5单位分别增加1.05 mmHg （95% CI, 0.12-1.98）。高血压的校正优势比分别为1.40 （95% CI, 1.07-1.83）、0.72 （95% CI, 0.53-0.97）和1.30 (95% CI, 1.05-1.61)，比较了钠、钾或钠钾比的最高和最低四分位数。我们的研究结果提供了基于人群的证据，表明同时高钠低钾摄入与高血压有关。
Studies indicate high sodium and low potassium intake can increase blood pressure suggesting the ratio of sodium-to-potassium may be informative. Yet, limited studies examine the association of the sodium-to-potassium ratio with blood pressure and hypertension. We analyzed data on 10,563 participants aged ≥20 years in the 2005–2010 National Health and Nutrition Examination Survey who were neither taking anti-hypertensive medication nor on a low sodium diet. We used measurement error models to estimate usual intakes, multivariable linear regression to assess their associations with blood pressure, and logistic regression to assess their associations with hypertension. The average usual intakes of sodium, potassium and sodium-to-potassium ratio were 3,569 mg/d, 2,745 mg/d, and 1.41, respectively. All three measures were significantly associated with systolic blood pressure, with an increase of 1.04 mmHg (95% CI, 0.27–1.82) and a decrease of 1.24 mmHg (95% CI, 0.31–2.70) per 1,000 mg/d increase in sodium or potassium intake, respectively, and an increase of 1.05 mmHg (95% CI, 0.12–1.98) per 0.5 unit increase in sodium-to-potassium ratio. The adjusted odds ratios for hypertension were 1.40 (95% CI, 1.07–1.83), 0.72 (95% CI, 0.53–0.97) and 1.30 (95% CI, 1.05–1.61), respectively, comparing the highest and lowest quartiles of usual intake of sodium, potassium or sodium-to-potassium ratio. Our results provide population-based evidence that concurrent higher sodium and lower potassium consumption are associated with hypertension.
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影响因子：
7.1
作者：
GRUCHOW, HW;SOBOCINSKI, KA;BARBORIAK, JJ
通讯作者：
BARBORIAK, JJ
影响因子：
4.2
作者：
Guenther, PM;Kott, PS;Carriquiry, AL
通讯作者：
Carriquiry, AL
影响因子：
4.9
作者：
Geleijnse, JM;Witteman, JCM;Grobbee, DE
通讯作者：
Grobbee, DE
影响因子：
5
作者：
KOK, FJ;VANDENBROUCKE, JP;VANDERHEIDE, RM
通讯作者：
VANDERHEIDE, RM
影响因子：
168.9
作者：
Lewington, S;Clarke, R;Collins, R
通讯作者：
Collins, R