Peek-a-boo: membrane hijacking and the pathogenesis of viral hepatitis.

Peek-a-boo: membrane hijacking and the pathogenesis of viral hepatitis.
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DOI:
10.1016/j.tim.2013.10.005
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发表时间:
2014-02
影响因子:
15.9
通讯作者:
Lemon, Stanley M.
Lemon, Stanley M.
中科院分区:
生物学1区
文献类型:
--
作者:
Feng, Zongdi;Lemon, Stanley M.

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从历史上看,动物病毒是根据是否存在包膜(通常携带一种或多种病毒糖蛋白的外部脂质双层膜)进行分类的。然而,越来越多的证据表明,一些“无包膜”病毒在感染者的血液中循环,这些病毒被宿主来源的膜包膜,从而提供免受中和抗体侵害的保护。在这篇评论文章中,我们讨论了这种病毒生存的新策略,并考虑它如何促进急性病毒性肝炎的发病机制。 “无包膜”病毒获得包膜极大地影响了它们在细胞和系统水平上与宿主的相互作用,并挑战了我们如何看待针对这些感染的疫苗保护。
Historically, animal viruses have been classified on the basis of the presence or absence of an envelope – an external lipid bilayer membrane typically carrying one or more viral glycoproteins. However, growing evidence indicates that some ‘non-enveloped’ viruses circulate in the blood of infected individuals enveloped in host-derived membranes that provide protection from neutralizing antibodies. In this opinion piece, we discuss this novel strategy for virus survival and consider how it contributes to the pathogenesis of acute viral hepatitis. The acquisition of an envelope by ‘non-enveloped’ viruses profoundly influences their interaction with the host at both the cellular and system level, and challenges how we think about vaccine protection against these infections.
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