TSLP enhances the function of helper type 2 cells.
TSLP enhances the function of helper type 2 cells.
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TSLP增强了辅助2型细胞的功能。
DOI：
10.1002/eji.201041195
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发表时间：
2011-07
影响因子：
5.4
通讯作者：
Ziegler, Steven F.
中科院分区：
文献类型：
--
作者：
Kitajima, Masayuki;Lee, Hai-Chon;Nakayama, Toshinori;Ziegler, Steven F.
细胞因子胸腺基质淋巴细胞生成素（TSLP）与人类和小鼠过敏性炎症的发生和进展有关。TSLP已显示通过上调树突状细胞上的OX 40 L和通过直接诱导幼稚CD 4 T细胞中的IL-4产生来促进Th 2型应答。然而，其对效应Th细胞的直接作用尚未得到广泛研究。在这项研究中，我们表明，小鼠效应Th 2细胞上的TSLPR表达水平高于Th 1和Th 17细胞，并且TSLP诱导效应Th 2细胞增殖，而不是Th 1和Th 17细胞。TSLP还诱导Th 2细胞中信号转导和转录激活因子（Stat）5的磷酸化以及抗凋亡因子Bcl-2的表达。最后，通过IL-4介导的TSLPR表达诱导，TCR刺激增强TSLP介导的Th 2细胞增殖。总之，这些结果表明TSLP通过直接刺激Th 2效应细胞参与Th 2环境中小鼠Th 2介导的过敏性炎症的恶化。
The cytokine thymic stromal lymphopoietin (TSLP) has been implicated in the development and progression of allergic inflammation in both humans and mice. TSLP has been shown to promote Th2-type response through upregulation of OX40L on dendritic cells, and through direct induction of IL-4 production in naïve CD4 T cells. However, its direct effect on effector Th cells has not been extensively investigated. In this study, we show that the level of TSLPR expression on mouse effector Th2 cells is higher than on Th1 and Th17 cells, and that TSLP induced proliferation of effector Th2, but not Th1 and Th17 cells. TSLP also induced the phosphorylation of Signal Transducer and Activator of Transcription (Stat) 5, and expression of anti-apoptotic factor Bcl-2 in Th2 cells. Finally, TSLP-mediated proliferation on Th2 cells was enhanced by TCR stimulation, through IL-4-mediated induction of TSLPR expression. Taken together, these results indicate that TSLP is involved in exacerbation of mouse Th2-mediated allergic inflammation in a Th2 environment through direct stimulation of Th2 effector cells.
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影响因子：
30.5
作者：
通讯作者：
--
影响因子：
4.4
作者：
Jessup, Heidi K.;Brewer, Avery W.;Comeau, Michael R.
通讯作者：
Comeau, Michael R.
DOI：
10.1073/pnas.0801532105
发表时间：
2008-08-19
影响因子：
11.1
作者：
He, Rui;Oyoshi, Michiko K.;Geha, Raif S.
通讯作者：
Geha, Raif S.
影响因子：
4.4
作者：
Reche, PA;Soumelis, V;Bazan, JF
通讯作者：
Bazan, JF
DOI：
10.1084/jem.192.5.659
发表时间：
2000-09-04
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Park LS;Martin U;Garka K;Gliniak B;Di Santo JP;Muller W;Largaespada DA;Copeland NG;Jenkins NA;Farr AG;Ziegler SF;Morrissey PJ;Paxton R;Sims JE
通讯作者：
Sims JE