Alzheimer disease and cognitive reserve: variation of education effect with carbon 11-labeled Pittsburgh Compound B uptake.
Alzheimer disease and cognitive reserve: variation of education effect with carbon 11-labeled Pittsburgh Compound B uptake.
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DOI：
10.1001/archneur.65.11.1467
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发表时间：
2008-11
影响因子：
--
通讯作者：
Morris, John C.
中科院分区：
文献类型：
--
作者：
Roe, Catherine M.;Mintun, Mark A.;D'Angelo, Gina;Xiong, Chengjie;Grant, Elizabeth A.;Morris, John C.
通过检查在纤维状脑淀粉样蛋白升高的情况下，受教育程度较高的个体是否比受教育程度较低的个体具有更好的认知功能，来评估认知储备假说。研究人员于2003年8月15日至2008年1月8日在华盛顿大学阿尔茨海默病研究中心评估了N-甲基-[11C]2-（4 ' -甲基氨基苯基）-6-羟基苯并噻唑（即匹兹堡化合物b的[11C]PIB）的摄取情况，这些参与者被诊断为非痴呆（N=161）或阿尔茨海默病型痴呆（N=37）。采用多元回归来确定[11C]PIB摄取是否与受教育程度相互作用以预测认知功能。临床痴呆评分-盒子总和（CDR-SB），迷你精神状态测试（MMSE）和简短祝福测试（SBT）的分数，以及心理测量电池的个人测量值。[11]PIB摄取与受教育年限相互作用，预测CDR-SB （p= 0.003）、MMSE （p< 0.001）、SBT （p= 0.03）和口头抽象推理和概念化测量（p= 0.02）的分数，因此，PIB摄取升高的参与者在这些测量上的表现随着受教育程度的增加而增加。在PIB摄取较低的人群中，教育程度与整体认知功能得分无关。这些结果支持认知储备影响阿尔茨海默病病理与认知之间关联的假设。
To evaluate the cognitive reserve hypothesis by examining whether individuals of greater educational attainment have better cognitive function than individuals with less education in the presence of elevated fibrillar brain amyloid. Uptake of N-methyl-[11C]2-(4′-methylaminophenyl)-6-hydroybenzothiazole, or [11C]PIB for “Pittsburgh Compound-B,” was measured for participants assessed between August 15, 2003 and January 8, 2008 at the Washington University Alzheimer’s Disease Research Center and diagnosed either as nondemented (N=161) or with dementia of the Alzheimer type (N=37). Multiple regression was used to determine whether [11C]PIB uptake interacted with level of educational attainment to predict cognitive function. Scores on the Clinical Dementia Rating - Sum of Boxes (CDR-SB), Mini-Mental State Exam (MMSE), and Short Blessed Test (SBT), and individual measures from a psychometric battery. [11C]PIB uptake interacted with years of education in predicting scores on the CDR-SB (p=.003), the MMSE (p<.001), the SBT (p=.03) and a measure of verbal abstract reasoning and conceptualization (p=.02), such that performance on these measures increased with increasing education for participants with elevated PIB uptake. Education was unrelated to global cognitive functioning scores among those with lower PIB uptake. These results support the hypothesis that cognitive reserve influences the association between Alzheimer disease pathology and cognition.
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影响因子：
11.2
作者：
MORRIS, JC;MCKEEL, DW;BERG, L
通讯作者：
BERG, L
影响因子：
6.3
作者：
LOGAN, J;FOWLER, JS;CHRISTMAN, DR
通讯作者：
CHRISTMAN, DR
影响因子：
11.2
作者：
BERG, L;MILLER, JP;FIGIEL, G
通讯作者：
FIGIEL, G
影响因子：
9.9
作者：
Storandt, Martha;Grant, Elizabeth A.;Morris, John C.
通讯作者：
Morris, John C.
影响因子：
4.8
作者：
FOLSTEIN, MF;FOLSTEIN, SE;MCHUGH, PR
通讯作者：
MCHUGH, PR