Relationships of serum CC16 levels with smoking status and lung function in COPD.
Relationships of serum CC16 levels with smoking status and lung function in COPD.
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DOI：
10.1186/s12931-022-02158-8
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发表时间：
2022-09-16
影响因子：
5.8
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中科院分区：
文献类型：
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俱乐部细胞分泌蛋白（CC 16）具有抗炎和抗氧化作用，低CC 16血清水平与COPD的风险和进展相关，但吸烟和CC 16对肺功能结局的相互作用仍不清楚。利用美国退伍军人的横截面数据，通过ELISA测量CC 16血清浓度，并进行对数转换用于分析。进行肺功能测定，COPD状态定义为使用支气管扩张剂后FEV 1/FVC比值< 0.7。吸烟措施是自我报告的问卷调查。采用多变量logistic和线性回归分析CC 16水平与COPD和肺功能之间的相关性，并对协变量进行调整。未经调整的皮尔逊相关性描述了CC 16水平和肺功能指标之间的关系，包年吸烟，戒烟年。研究人群（N = 351）大多为男性、白色，平均年龄超过60岁。在COPD受试者中证实了CC 16和吸烟状态对FEV 1/FVC比值的相互作用（N = 245，p = 0.01）。既往吸烟者与COPD呈正相关，目前吸烟者和从不吸烟者与COPD呈负相关。在患有COPD的前吸烟者中，CC 16水平与戒烟后的年数呈正相关，与吸烟包年数呈负相关。CC 16水平升高与COPD发生率降低相关（ORadj = 0.36，95%CI 0.22-0.57，Padj < 0.0001）。吸烟状况是CC 16与肺功能关系的重要影响因素。在患有COPD的既往吸烟者中，血清CC 16升高对应于FEV 1/FVC比值的升高，而在当前或从不吸烟者中，则呈相反关系。可能需要额外的纵向研究来评估CC 16与戒烟对COPD受试者肺功能的关系。在线版本包含补充材料，可通过10.1186/s12931-022-02158-8获得。
The club cell secretory protein (CC16) has anti-inflammatory and antioxidant effects, and low CC16 serum levels have been associated with both risk and progression of COPD, yet the interaction between smoking and CC16 on lung function outcomes remains unknown. Utilizing cross-sectional data on United States veterans, CC16 serum concentrations were measured by ELISA and log transformed for analyses. Spirometry was conducted and COPD status was defined by post-bronchodilator FEV1/FVC ratio < 0.7. Smoking measures were self-reported on questionnaire. Multivariable logistic and linear regression were employed to examine associations between CC16 levels and COPD, and lung function with adjustment for covariates. Unadjusted Pearson correlations described relationships between CC16 level and lung function measures, pack-years smoked, and years since smoking cessation. The study population (N = 351) was mostly male, white, with an average age over 60 years. An interaction between CC16 and smoking status on FEV1/FVC ratio was demonstrated among subjects with COPD (N = 245, p = 0.01). There was a positive correlation among former smokers and negative correlation among current or never smokers with COPD. Among former smokers with COPD, CC16 levels were also positively correlated with years since smoking cessation, and inversely related with pack-years smoked. Increasing CC16 levels were associated with lower odds of COPD (ORadj = 0.36, 95% CI 0.22–0.57, Padj < 0.0001). Smoking status is an important effect modifier of CC16 relationships with lung function. Increasing serum CC16 corresponded to increases in FEV1/FVC ratio in former smokers with COPD versus opposite relationships in current or never smokers. Additional longitudinal studies may be warranted to assess relationship of CC16 with smoking cessation on lung function among subjects with COPD. The online version contains supplementary material available at 10.1186/s12931-022-02158-8.
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