Bimodal imaging probes for combined PET and OI: recent developments and future directions for hybrid agent development.
Bimodal imaging probes for combined PET and OI: recent developments and future directions for hybrid agent development.
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DOI：
10.1155/2014/153741
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发表时间：
2014
影响因子：
--
通讯作者：
Wängler C
中科院分区：
文献类型：
--
作者：
Seibold U;Wängler B;Schirrmacher R;Wängler C
分子成像，特别是正电子发射断层扫描（PET），已经获得了越来越多的重要性，用于诊断各种疾病，因此，经验越来越多的传播。因此，对特异性地积累和可视化人体中的靶结构的高度仿射PET示踪剂的需求也在不断增长。除了开发适合单独用于PET的试剂之外，最近的趋势旨在合成适用于PET以及光学成像（OI）的双峰成像探针，因为这种模式的组合可以提供临床优势。由于PET核素发射的γ辐射的高组织穿透性，PET允许能够识别和可视化全身中的肿瘤和转移的定量成像。相反，OI使仅表现出有限的组织穿透的光子可视化，但是使得能够在手术期间识别肿瘤边缘和感染的淋巴结，而不会为外科医生带来辐射负担。因此，为了利用这两种成像技术用于肿瘤疾病的成像和治疗的潜力，对PET和OI的双峰剂产生了新的兴趣。这篇简短的评论总结了现有的混合探针开发的双重PET和OI，并讨论了未来的方向混合剂的发展。
Molecular imaging—and especially positron emission tomography (PET)—has gained increasing importance for diagnosis of various diseases and thus experiences an increasing dissemination. Therefore, there is also a growing demand for highly affine PET tracers specifically accumulating and visualizing target structures in the human body. Beyond the development of agents suitable for PET alone, recent tendencies aim at the synthesis of bimodal imaging probes applicable in PET as well as optical imaging (OI), as this combination of modalities can provide clinical advantages. PET, due to the high tissue penetration of the γ-radiation emitted by PET nuclides, allows a quantitative imaging able to identify and visualize tumors and metastases in the whole body. OI on the contrary visualizes photons exhibiting only a limited tissue penetration but enables the identification of tumor margins and infected lymph nodes during surgery without bearing a radiation burden for the surgeon. Thus, there is an emerging interest in bimodal agents for PET and OI in order to exploit the potential of both imaging techniques for the imaging and treatment of tumor diseases. This short review summarizes the available hybrid probes developed for dual PET and OI and discusses future directions for hybrid agent development.
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DOI：
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