Toward an understanding of the pathophysiology of clear cell carcinoma of the ovary (Review).
Toward an understanding of the pathophysiology of clear cell carcinoma of the ovary (Review).
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DOI：
10.3892/ol.2013.1550
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发表时间：
2013-11
期刊：
影响因子：
2.9
通讯作者：
Kobayashi H
中科院分区：
文献类型：
--
作者：
Uekuri C;Shigetomi H;Ono S;Sasaki Y;Matsuura M;Kobayashi H
Endometriosis-associated ovarian cancers demonstrate substantial morphological and genetic diversity. The transcription factor, hepatocyte nuclear factor (HNF)-1β, may be one of several key genes involved in the identity of ovarian clear cell carcinoma (CCC). The present study reviews a considerably expanded set of HNF-1β-associated genes and proteins that determine the pathophysiology of CCC. The current literature was reviewed by searching MEDLINE/PubMed. Functional interpretations of gene expression profiling in CCC are provided. Several important CCC-related genes overlap with those known to be regulated by the upregulation of HNF-1β expression, along with a lack of estrogen receptor (ER) expression. Furthermore, the genetic expression pattern in CCC resembles that of the Arias-Stella reaction, decidualization and placentation. HNF-1β regulates a subset of progesterone target genes. HNF-1β may also act as a modulator of female reproduction, playing a role in endometrial regeneration, differentiation, decidualization, glycogen synthesis, detoxification, cell cycle regulation, implantation, uterine receptivity and a successful pregnancy. In conclusion, the present study focused on reviewing the aberrant expression of CCC-specific genes and provided an update on the pathological implications and molecular functions of well-characterized CCC-specific genes.
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影响因子：
2.7
作者：
Bulun SE;Cheng YH;Pavone ME;Xue Q;Attar E;Trukhacheva E;Tokunaga H;Utsunomiya H;Yin P;Luo X;Lin Z;Imir G;Thung S;Su EJ;Kim JJ
通讯作者：
Kim JJ
影响因子：
4.6
作者：
D'Angelo, Anna;Bluteau, Olivier;Pontoglio, Marco
通讯作者：
Pontoglio, Marco
影响因子：
2.9
作者：
Higashiura, Yumi;Kajihara, Hirotaka;Kobayashi, Hiroshi
通讯作者：
Kobayashi, Hiroshi
影响因子：
3.5
作者：
Itamochi, H;Kigawa, J;Terakawa, N
通讯作者：
Terakawa, N
DOI：
10.1158/1055-9965.epi-08-1214
发表时间：
2009-05
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Hecht JL;Kotsopoulos J;Hankinson SE;Tworoger SS
通讯作者：
Tworoger SS