Preliminary investigation of miRNA expression in individuals at high familial risk of bipolar disorder.
Preliminary investigation of miRNA expression in individuals at high familial risk of bipolar disorder.
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DOI：
10.1016/j.jpsychires.2015.01.006
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发表时间：
2015-03
影响因子：
4.8
通讯作者：
Evans, Kathryn Louise
中科院分区：
文献类型：
--
作者：
Walker, Rosie May;Rybka, Joanna;Anderson, Susan Maguire;Torrance, Helen Scott;Boxall, Ruth;Sussmann, Jessika Elizabeth;Porteous, David John;McIntosh, Andrew Mark;Evans, Kathryn Louise
双相情感障碍（BD）是一种高度遗传的精神疾病，其特征是反复发作的躁狂和抑郁。许多研究报道了BD中基因表达的改变，其中一些可能归因于miRNA的表达失调。迄今为止进行的研究主要研究了药物治疗的患者，因此观察到的miRNA表达的变化可能是临床疾病或其治疗的结果。我们试图通过研究BD患者的年轻、未用药亲属来确定改变的miRNA表达是否可能在BD的发展中发挥致病作用，这些BD患者本身具有较高的遗传风险（高风险个体）。通过qRT-PCR在来自34个高风险个体和46个对照个体的全血样本中测量了先前与BD或精神分裂症有关的20种miRNA的表达。三种miRNAs，miR-15 b，miR-132和miR-652在高危个体中上调，与先前报道的这些miRNAs在精神分裂症患者中表达增加一致。我们的研究结果表明，这些miRNA的表达改变可能代表了BD遗传易感性的机制。此外，我们观察到疾病发作前血液中miRNA表达的改变，这为有朝一日基于血液的检测可能有助于BD的风险分层和治疗提供了希望。双相情感障碍患者未服药亲属中测量的miRNA表达确定miR-15 b、miR-132和miR-652显著上调。确定了这些miRNAs的已知和预测靶点。这些miRNAs的靶点与双相情感障碍的功能有关。
Bipolar disorder (BD) is a highly heritable psychiatric disorder characterised by recurrent episodes of mania and depression. Many studies have reported altered gene expression in BD, some of which may be attributable to the dysregulated expression of miRNAs. Studies carried out to date have largely studied medicated patients, so it is possible that observed changes in miRNA expression might be a consequence of clinical illness or of its treatment. We sought to establish whether altered miRNA expression might play a causative role in the development of BD by studying young, unmedicated relatives of individuals with BD, who are at a higher genetic risk of developing BD themselves (high-risk individuals). The expression of 20 miRNAs previously implicated in either BD or schizophrenia was measured by qRT-PCR in whole-blood samples from 34 high-risk and 46 control individuals. Three miRNAs, miR-15b, miR-132 and miR-652 were up-regulated in the high-risk individuals, consistent with previous reports of increased expression of these miRNAs in patients with schizophrenia. Our findings suggest that the altered expression of these miRNAs might represent a mechanism of genetic susceptibility for BD. Moreover, our observation of altered miRNA expression in the blood prior to the onset of illness provides hope that one day blood-based tests may aid in the risk-stratification and treatment of BD. Measured miRNA expression in unmedicated relatives of bipolar disorder patients. Identified miR-15b, miR-132 and miR-652 as being significantly up-regulated. Identified known and predicted targets of these miRNAs. Targets of these miRNAs are involved in functions implicated in bipolar disorder.
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影响因子：
5.6
作者：
Finnerty JR;Wang WX;Hébert SS;Wilfred BR;Mao G;Nelson PT
通讯作者：
Nelson PT
精神分裂症和躁郁症患者前额皮质中的 MicroRNA 表达谱。
影响因子：
4.5
作者：
Kim, Albert H.;Reimers, Mark;Mahera, Brion;Williamson, Vernell;McMichael, Omari I.;McClay, Joseph L.;van den Oord, Edwin J. C. G.;Riley, Brien P.;Kendler, Kenneth S.;Vladimirov, Vladimir I.
通讯作者：
Vladimirov, Vladimir I.
影响因子：
--
作者：
Kitagishi Y;Kobayashi M;Matsuda S
通讯作者：
Matsuda S
影响因子：
4.7
作者：
Folsom TD;Fatemi SH
通讯作者：
Fatemi SH
影响因子：
10.6
作者：
Moreau, Michael P.;Bruse, Shannon E.;David-Rus, Richard;Buyske, Steven;Brzustowicz, Linda M.
通讯作者：
Brzustowicz, Linda M.